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GIP Receptor Antagonist, SKL-14959 Indicated Alteration of the Lipids Metabolism to Catabolism by the Inhibition of Plasma LPL Activity, Resulting in the Suppression of Weight Gain on Diets-Induced Obesity Mice
INTRODUCTION: Glucose-dependent insulinotropic polypeptide (GIP) plays a crucial role in the regulation of lipid metabolism via lipoprotein lipase (LPL). GIP receptor antagonist, SKL-14959, suppressed the weight gain in the diet-induced obesity model. However, the mechanism is not unclear. Therefore...
Autores principales: | Nakamura, Takashi, Tanimoto, Hitomi, Okamoto, Masayuki, Takeuchi, Mitsuaki, Tsubamoto, Yoshiharu, Noda, Hitoshi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955685/ https://www.ncbi.nlm.nih.gov/pubmed/33727843 http://dx.doi.org/10.2147/DMSO.S297353 |
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