Validation and performance comparison of two SARS-CoV-2 IgG/IgM rapid tests

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a disease called COVID-19. COVID-19 is primarily diagnosed using molecular techniques mainly real-time reverse transcriptase PCR. Reliable and accurate serologic assays for COVID-19, are an important tool for surveillance and epidem...

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Autores principales: Al Awaji, Nisreen Naser, Ahmedah, Hanadi Talal, Alsaady, Isra Mohammed, Bawaked, Rowaedh Ahmed, Alraey, Mohammed A., Alasiri, Ahmed Ayed, Alfaifi, Abdullah Mofareh, Alshehri, Hamdan Ali, Alserihi, Raed, Yasin, Elrashed B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955801/
https://www.ncbi.nlm.nih.gov/pubmed/33746537
http://dx.doi.org/10.1016/j.sjbs.2021.03.007
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author Al Awaji, Nisreen Naser
Ahmedah, Hanadi Talal
Alsaady, Isra Mohammed
Bawaked, Rowaedh Ahmed
Alraey, Mohammed A.
Alasiri, Ahmed Ayed
Alfaifi, Abdullah Mofareh
Alshehri, Hamdan Ali
Alserihi, Raed
Yasin, Elrashed B.
author_facet Al Awaji, Nisreen Naser
Ahmedah, Hanadi Talal
Alsaady, Isra Mohammed
Bawaked, Rowaedh Ahmed
Alraey, Mohammed A.
Alasiri, Ahmed Ayed
Alfaifi, Abdullah Mofareh
Alshehri, Hamdan Ali
Alserihi, Raed
Yasin, Elrashed B.
author_sort Al Awaji, Nisreen Naser
collection PubMed
description Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a disease called COVID-19. COVID-19 is primarily diagnosed using molecular techniques mainly real-time reverse transcriptase PCR. Reliable and accurate serologic assays for COVID-19, are an important tool for surveillance and epidemiologic studies. In this study, the IgG/IgM Rapid Test Cassette and the Prima COVID-19 IgG/IgM Rapid Test for the detection of SARS-CoV-2 antibodies in blood, serum and plasma samples collected from patients up to 48 days after symptom onset in Saudi Arabia were validated. Overall, both tests showed poor performance and cannot be utilised for COVID-19 diagnosis as a point of care test or to determine seroprevalence.
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spelling pubmed-79558012021-03-15 Validation and performance comparison of two SARS-CoV-2 IgG/IgM rapid tests Al Awaji, Nisreen Naser Ahmedah, Hanadi Talal Alsaady, Isra Mohammed Bawaked, Rowaedh Ahmed Alraey, Mohammed A. Alasiri, Ahmed Ayed Alfaifi, Abdullah Mofareh Alshehri, Hamdan Ali Alserihi, Raed Yasin, Elrashed B. Saudi J Biol Sci Original Article Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a disease called COVID-19. COVID-19 is primarily diagnosed using molecular techniques mainly real-time reverse transcriptase PCR. Reliable and accurate serologic assays for COVID-19, are an important tool for surveillance and epidemiologic studies. In this study, the IgG/IgM Rapid Test Cassette and the Prima COVID-19 IgG/IgM Rapid Test for the detection of SARS-CoV-2 antibodies in blood, serum and plasma samples collected from patients up to 48 days after symptom onset in Saudi Arabia were validated. Overall, both tests showed poor performance and cannot be utilised for COVID-19 diagnosis as a point of care test or to determine seroprevalence. Elsevier 2021-06 2021-03-14 /pmc/articles/PMC7955801/ /pubmed/33746537 http://dx.doi.org/10.1016/j.sjbs.2021.03.007 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Al Awaji, Nisreen Naser
Ahmedah, Hanadi Talal
Alsaady, Isra Mohammed
Bawaked, Rowaedh Ahmed
Alraey, Mohammed A.
Alasiri, Ahmed Ayed
Alfaifi, Abdullah Mofareh
Alshehri, Hamdan Ali
Alserihi, Raed
Yasin, Elrashed B.
Validation and performance comparison of two SARS-CoV-2 IgG/IgM rapid tests
title Validation and performance comparison of two SARS-CoV-2 IgG/IgM rapid tests
title_full Validation and performance comparison of two SARS-CoV-2 IgG/IgM rapid tests
title_fullStr Validation and performance comparison of two SARS-CoV-2 IgG/IgM rapid tests
title_full_unstemmed Validation and performance comparison of two SARS-CoV-2 IgG/IgM rapid tests
title_short Validation and performance comparison of two SARS-CoV-2 IgG/IgM rapid tests
title_sort validation and performance comparison of two sars-cov-2 igg/igm rapid tests
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955801/
https://www.ncbi.nlm.nih.gov/pubmed/33746537
http://dx.doi.org/10.1016/j.sjbs.2021.03.007
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