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Efficacy of single-session transcranial direct current stimulation on addiction-related inhibitory control and craving: a randomized trial in males with Internet gaming disorder

BACKGROUND: Transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (dlPFC) may reduce substance use and other addictive behaviours. However, the cognitive mechanisms that underpin such effects remain unclear. Impaired inhibitory control linked to hypoactivation of the p...

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Autores principales: Wu, Lu-lu, Potenza, Marc N., Zhou, Nan, Kober, Hedy, Shi, Xin-hui, Yip, Sarah W., Xu, Jia-hua, Zhu, Lei, Wang, Rui, Liu, Guan-qun, Zhang, Jin-tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Joule Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955853/
https://www.ncbi.nlm.nih.gov/pubmed/33119491
http://dx.doi.org/10.1503/jpn.190137
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author Wu, Lu-lu
Potenza, Marc N.
Zhou, Nan
Kober, Hedy
Shi, Xin-hui
Yip, Sarah W.
Xu, Jia-hua
Zhu, Lei
Wang, Rui
Liu, Guan-qun
Zhang, Jin-tao
author_facet Wu, Lu-lu
Potenza, Marc N.
Zhou, Nan
Kober, Hedy
Shi, Xin-hui
Yip, Sarah W.
Xu, Jia-hua
Zhu, Lei
Wang, Rui
Liu, Guan-qun
Zhang, Jin-tao
author_sort Wu, Lu-lu
collection PubMed
description BACKGROUND: Transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (dlPFC) may reduce substance use and other addictive behaviours. However, the cognitive mechanisms that underpin such effects remain unclear. Impaired inhibitory control linked to hypoactivation of the prefrontal cortex may allow craving-related motivations to lead to compulsive addictive behaviours. However, very few studies have examined whether increasing the activation of the dlPFC via anodal tDCS could enhance inhibitory control over addiction-related distractors. The current study aimed to enrich empirical evidence related to this issue. METHODS: Thirty-three males with Internet gaming disorder underwent active (1.5 mA for 20 minutes) and sham tDCS 1 week apart, in randomized order. We assessed inhibitory control over gaming-related distractors and craving pre- and post-stimulation. RESULTS: Relative to sham treatment, active tDCS reduced interference from gaming-related (versus non-gaming) distractors and attenuated background craving, but did not affect cue-induced craving. LIMITATIONS: This study was limited by its relatively small sample size and the fact that it lacked assessments of tDCS effects on addictive behaviour. Future tDCS studies with multiple sessions in larger samples are warranted to examine the effects on addictive behaviours of alterations in addiction-related inhibitory control. CONCLUSION: These findings demonstrate that stimulation of the dlPFC influences inhibitory control over addiction-related cues and addiction-related motivation. This is the first empirical study to suggest that enhanced inhibitory control may be a cognitive mechanism underlying the effects of tDCS on addictions like Internet gaming disorder. Our finding of attenuated background craving replicated previous tDCS studies. Intriguingly, our finding of distinct tDCS effects on 2 forms of craving suggests that they may have disparate underlying mechanisms or differential sensitivity to tDCS. CLINICAL TRIALS NO: NCT03352973
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spelling pubmed-79558532021-03-19 Efficacy of single-session transcranial direct current stimulation on addiction-related inhibitory control and craving: a randomized trial in males with Internet gaming disorder Wu, Lu-lu Potenza, Marc N. Zhou, Nan Kober, Hedy Shi, Xin-hui Yip, Sarah W. Xu, Jia-hua Zhu, Lei Wang, Rui Liu, Guan-qun Zhang, Jin-tao J Psychiatry Neurosci Research Paper BACKGROUND: Transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (dlPFC) may reduce substance use and other addictive behaviours. However, the cognitive mechanisms that underpin such effects remain unclear. Impaired inhibitory control linked to hypoactivation of the prefrontal cortex may allow craving-related motivations to lead to compulsive addictive behaviours. However, very few studies have examined whether increasing the activation of the dlPFC via anodal tDCS could enhance inhibitory control over addiction-related distractors. The current study aimed to enrich empirical evidence related to this issue. METHODS: Thirty-three males with Internet gaming disorder underwent active (1.5 mA for 20 minutes) and sham tDCS 1 week apart, in randomized order. We assessed inhibitory control over gaming-related distractors and craving pre- and post-stimulation. RESULTS: Relative to sham treatment, active tDCS reduced interference from gaming-related (versus non-gaming) distractors and attenuated background craving, but did not affect cue-induced craving. LIMITATIONS: This study was limited by its relatively small sample size and the fact that it lacked assessments of tDCS effects on addictive behaviour. Future tDCS studies with multiple sessions in larger samples are warranted to examine the effects on addictive behaviours of alterations in addiction-related inhibitory control. CONCLUSION: These findings demonstrate that stimulation of the dlPFC influences inhibitory control over addiction-related cues and addiction-related motivation. This is the first empirical study to suggest that enhanced inhibitory control may be a cognitive mechanism underlying the effects of tDCS on addictions like Internet gaming disorder. Our finding of attenuated background craving replicated previous tDCS studies. Intriguingly, our finding of distinct tDCS effects on 2 forms of craving suggests that they may have disparate underlying mechanisms or differential sensitivity to tDCS. CLINICAL TRIALS NO: NCT03352973 Joule Inc. 2021-01 /pmc/articles/PMC7955853/ /pubmed/33119491 http://dx.doi.org/10.1503/jpn.190137 Text en © 2021 Joule Inc. or its licensors This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY-NC-ND 4.0) licence, which permits use, distribution and reproduction in any medium, provided that the original publication is properly cited, the use is non-commercial (i.e. research or educational use), and no modifications or adaptations are made. See: https://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Research Paper
Wu, Lu-lu
Potenza, Marc N.
Zhou, Nan
Kober, Hedy
Shi, Xin-hui
Yip, Sarah W.
Xu, Jia-hua
Zhu, Lei
Wang, Rui
Liu, Guan-qun
Zhang, Jin-tao
Efficacy of single-session transcranial direct current stimulation on addiction-related inhibitory control and craving: a randomized trial in males with Internet gaming disorder
title Efficacy of single-session transcranial direct current stimulation on addiction-related inhibitory control and craving: a randomized trial in males with Internet gaming disorder
title_full Efficacy of single-session transcranial direct current stimulation on addiction-related inhibitory control and craving: a randomized trial in males with Internet gaming disorder
title_fullStr Efficacy of single-session transcranial direct current stimulation on addiction-related inhibitory control and craving: a randomized trial in males with Internet gaming disorder
title_full_unstemmed Efficacy of single-session transcranial direct current stimulation on addiction-related inhibitory control and craving: a randomized trial in males with Internet gaming disorder
title_short Efficacy of single-session transcranial direct current stimulation on addiction-related inhibitory control and craving: a randomized trial in males with Internet gaming disorder
title_sort efficacy of single-session transcranial direct current stimulation on addiction-related inhibitory control and craving: a randomized trial in males with internet gaming disorder
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955853/
https://www.ncbi.nlm.nih.gov/pubmed/33119491
http://dx.doi.org/10.1503/jpn.190137
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