Reduction of Depression in Diabetes: A New Pleiotropic Action of Metformin?

Metformin remains the cornerstone of management for type 2 diabetes mellitus (T2DM). It is also known that it has beneficial pleiotropic actions. In addition, there is emerging evidence that this agent may prove beneficial in ameliorating depression in T2DM. The underlying mechanisms of this new act...

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Autores principales: Papachristou, Stella, Papanas, Nikolaos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2021
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955898/
https://www.ncbi.nlm.nih.gov/pubmed/33715080
http://dx.doi.org/10.1007/s13300-021-01044-8
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author Papachristou, Stella
Papanas, Nikolaos
author_facet Papachristou, Stella
Papanas, Nikolaos
author_sort Papachristou, Stella
collection PubMed
description Metformin remains the cornerstone of management for type 2 diabetes mellitus (T2DM). It is also known that it has beneficial pleiotropic actions. In addition, there is emerging evidence that this agent may prove beneficial in ameliorating depression in T2DM. The underlying mechanisms of this new action remain elusive, but experimental studies point to improved synaptic function and increased serotonin activity, along with the known inflammatory and antioxidant properties of metformin. Obviously, we need to further explore the potential utility of such antidepressant effects among T2DM subjects in everyday reality.
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spelling pubmed-79558982021-03-15 Reduction of Depression in Diabetes: A New Pleiotropic Action of Metformin? Papachristou, Stella Papanas, Nikolaos Diabetes Ther Editorial Metformin remains the cornerstone of management for type 2 diabetes mellitus (T2DM). It is also known that it has beneficial pleiotropic actions. In addition, there is emerging evidence that this agent may prove beneficial in ameliorating depression in T2DM. The underlying mechanisms of this new action remain elusive, but experimental studies point to improved synaptic function and increased serotonin activity, along with the known inflammatory and antioxidant properties of metformin. Obviously, we need to further explore the potential utility of such antidepressant effects among T2DM subjects in everyday reality. Springer Healthcare 2021-03-14 2021-04 /pmc/articles/PMC7955898/ /pubmed/33715080 http://dx.doi.org/10.1007/s13300-021-01044-8 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Editorial
Papachristou, Stella
Papanas, Nikolaos
Reduction of Depression in Diabetes: A New Pleiotropic Action of Metformin?
title Reduction of Depression in Diabetes: A New Pleiotropic Action of Metformin?
title_full Reduction of Depression in Diabetes: A New Pleiotropic Action of Metformin?
title_fullStr Reduction of Depression in Diabetes: A New Pleiotropic Action of Metformin?
title_full_unstemmed Reduction of Depression in Diabetes: A New Pleiotropic Action of Metformin?
title_short Reduction of Depression in Diabetes: A New Pleiotropic Action of Metformin?
title_sort reduction of depression in diabetes: a new pleiotropic action of metformin?
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955898/
https://www.ncbi.nlm.nih.gov/pubmed/33715080
http://dx.doi.org/10.1007/s13300-021-01044-8
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