Monte Carlo Simulation Method Highlighting on the Electron Beam Irradiation on the Structure of SARS-CoV-2

The outbreak of SARS-CoV-2 resulted in more than 11 000 000 infections and over 530 000 deaths. Coronavirus (S) spike glycoproteins promote entry into cells and are the main target of antibodies. We studied the effect of electron beams on the SARS CoV-2 glycoprotein and also on RNA using Monte Carlo...

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Autores principales: Bardane, Adil, Tajmouati, Jaouad, Maghnouj, Abdelmajid, Dadouch, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pleiades Publishing 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955905/
http://dx.doi.org/10.3103/S0027134920060041
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author Bardane, Adil
Tajmouati, Jaouad
Maghnouj, Abdelmajid
Dadouch, Ahmed
author_facet Bardane, Adil
Tajmouati, Jaouad
Maghnouj, Abdelmajid
Dadouch, Ahmed
author_sort Bardane, Adil
collection PubMed
description The outbreak of SARS-CoV-2 resulted in more than 11 000 000 infections and over 530 000 deaths. Coronavirus (S) spike glycoproteins promote entry into cells and are the main target of antibodies. We studied the effect of electron beams on the SARS CoV-2 glycoprotein and also on RNA using Monte Carlo simulation. We demonstrated that S-SARS CoV peak glycoproteins damaged by irradiation electrons corresponding to an energy loss of approximately 1.2 keV with a damage rate of the efficiency that can be as high as [Formula: see text].
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spelling pubmed-79559052021-03-15 Monte Carlo Simulation Method Highlighting on the Electron Beam Irradiation on the Structure of SARS-CoV-2 Bardane, Adil Tajmouati, Jaouad Maghnouj, Abdelmajid Dadouch, Ahmed Moscow Univ. Phys. Article The outbreak of SARS-CoV-2 resulted in more than 11 000 000 infections and over 530 000 deaths. Coronavirus (S) spike glycoproteins promote entry into cells and are the main target of antibodies. We studied the effect of electron beams on the SARS CoV-2 glycoprotein and also on RNA using Monte Carlo simulation. We demonstrated that S-SARS CoV peak glycoproteins damaged by irradiation electrons corresponding to an energy loss of approximately 1.2 keV with a damage rate of the efficiency that can be as high as [Formula: see text]. Pleiades Publishing 2021-03-14 2020 /pmc/articles/PMC7955905/ http://dx.doi.org/10.3103/S0027134920060041 Text en © Allerton Press, Inc. 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Bardane, Adil
Tajmouati, Jaouad
Maghnouj, Abdelmajid
Dadouch, Ahmed
Monte Carlo Simulation Method Highlighting on the Electron Beam Irradiation on the Structure of SARS-CoV-2
title Monte Carlo Simulation Method Highlighting on the Electron Beam Irradiation on the Structure of SARS-CoV-2
title_full Monte Carlo Simulation Method Highlighting on the Electron Beam Irradiation on the Structure of SARS-CoV-2
title_fullStr Monte Carlo Simulation Method Highlighting on the Electron Beam Irradiation on the Structure of SARS-CoV-2
title_full_unstemmed Monte Carlo Simulation Method Highlighting on the Electron Beam Irradiation on the Structure of SARS-CoV-2
title_short Monte Carlo Simulation Method Highlighting on the Electron Beam Irradiation on the Structure of SARS-CoV-2
title_sort monte carlo simulation method highlighting on the electron beam irradiation on the structure of sars-cov-2
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955905/
http://dx.doi.org/10.3103/S0027134920060041
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