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Genetic modification to design a stable yeast-expressed recombinant SARS-CoV-2 receptor binding domain as a COVID-19 vaccine candidate

BACKGROUND: Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has now spread worldwide to infect over 110 million people, with approximately 2.5 million reported deaths. A safe and effective vaccine remains urgently needed. METHOD: We constructed three variants of the recombinant receptor-bin...

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Detalles Bibliográficos
Autores principales:	Chen, Wen-Hsiang, Wei, Junfei, Kundu, Rakhi Tyagi, Adhikari, Rakesh, Liu, Zhuyun, Lee, Jungsoon, Versteeg, Leroy, Poveda, Cristina, Keegan, Brian, Villar, Maria Jose, de Araujo Leao, Ana C., Rivera, Joanne Altieri, Gillespie, Portia M., Pollet, Jeroen, Strych, Ulrich, Zhan, Bin, Hotez, Peter J., Bottazzi, Maria Elena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier B.V. 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955913/ https://www.ncbi.nlm.nih.gov/pubmed/33731300 http://dx.doi.org/10.1016/j.bbagen.2021.129893

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