Cytotoxic and apoptotic potential of some coumarin and 2-amino-3-carbonitrile selenophene derivatives in prostate cancer

3-acetyl coumarin derivatives (1a-d) are formed as a result of condensation of salicylaldehyde derivatives and ethyl acetoacetate and were converted into coumarin-selenophene hybrid compounds (2a-d) in the basic medium by modified Gewald reaction in the presence of malononitrile and selenium. Produc...

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Autores principales: YILDIRIM, Metin, ERSATIR, Mehmet, ARSLAN, Badel, GİRAY, Elife Sultan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Scientific and Technological Research Council of Turkey 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955924/
https://www.ncbi.nlm.nih.gov/pubmed/33737857
http://dx.doi.org/10.3906/kim-2008-56
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author YILDIRIM, Metin
ERSATIR, Mehmet
ARSLAN, Badel
GİRAY, Elife Sultan
author_facet YILDIRIM, Metin
ERSATIR, Mehmet
ARSLAN, Badel
GİRAY, Elife Sultan
author_sort YILDIRIM, Metin
collection PubMed
description 3-acetyl coumarin derivatives (1a-d) are formed as a result of condensation of salicylaldehyde derivatives and ethyl acetoacetate and were converted into coumarin-selenophene hybrid compounds (2a-d) in the basic medium by modified Gewald reaction in the presence of malononitrile and selenium. Products are characterized by nuclear magnetic resonance (NMR). The prepared compounds are screened for their anticancer activity against DU-145 cell line. In addition, selected target compounds are evaluated for apoptosis and oxidative stress on DU-145 (prostate carcinoma) cell lines.
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spelling pubmed-79559242021-03-17 Cytotoxic and apoptotic potential of some coumarin and 2-amino-3-carbonitrile selenophene derivatives in prostate cancer YILDIRIM, Metin ERSATIR, Mehmet ARSLAN, Badel GİRAY, Elife Sultan Turk J Chem Article 3-acetyl coumarin derivatives (1a-d) are formed as a result of condensation of salicylaldehyde derivatives and ethyl acetoacetate and were converted into coumarin-selenophene hybrid compounds (2a-d) in the basic medium by modified Gewald reaction in the presence of malononitrile and selenium. Products are characterized by nuclear magnetic resonance (NMR). The prepared compounds are screened for their anticancer activity against DU-145 cell line. In addition, selected target compounds are evaluated for apoptosis and oxidative stress on DU-145 (prostate carcinoma) cell lines. The Scientific and Technological Research Council of Turkey 2021-02-17 /pmc/articles/PMC7955924/ /pubmed/33737857 http://dx.doi.org/10.3906/kim-2008-56 Text en Copyright © 2021 The Author(s) This article is distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Article
YILDIRIM, Metin
ERSATIR, Mehmet
ARSLAN, Badel
GİRAY, Elife Sultan
Cytotoxic and apoptotic potential of some coumarin and 2-amino-3-carbonitrile selenophene derivatives in prostate cancer
title Cytotoxic and apoptotic potential of some coumarin and 2-amino-3-carbonitrile selenophene derivatives in prostate cancer
title_full Cytotoxic and apoptotic potential of some coumarin and 2-amino-3-carbonitrile selenophene derivatives in prostate cancer
title_fullStr Cytotoxic and apoptotic potential of some coumarin and 2-amino-3-carbonitrile selenophene derivatives in prostate cancer
title_full_unstemmed Cytotoxic and apoptotic potential of some coumarin and 2-amino-3-carbonitrile selenophene derivatives in prostate cancer
title_short Cytotoxic and apoptotic potential of some coumarin and 2-amino-3-carbonitrile selenophene derivatives in prostate cancer
title_sort cytotoxic and apoptotic potential of some coumarin and 2-amino-3-carbonitrile selenophene derivatives in prostate cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955924/
https://www.ncbi.nlm.nih.gov/pubmed/33737857
http://dx.doi.org/10.3906/kim-2008-56
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