Cargando…

Protective Effect of Thymus serrulatus Essential Oil on Cadmium-Induced Nephrotoxicity in Rats, through Suppression of Oxidative Stress and Downregulation of NF-κB, iNOS, and Smad2 mRNA Expression

The purpose of the research was to examine the protective effect of essential oil from Thymus serrulatus Hochst. ex Benth. (TSA oil) against cadmium (Cd)-induced renal toxicity. The experimental protocol was designed using 30 healthy adult Wistar albino rats allocated into five groups containing six...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ansari, Mohd Nazam, Rehman, Najeeb Ur, Karim, Aman, Imam, Faisal, Hamad, Abubaker M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956168/ https://www.ncbi.nlm.nih.gov/pubmed/33652584 http://dx.doi.org/10.3390/molecules26051252

Ejemplares similares

Possible Tracheal Relaxant and Antimicrobial Effects of the Essential Oil of Ethiopian Thyme Species (Thymus serrulatus Hochst. ex Benth.): A Multiple Mechanistic Approach
por: Rehman, Najeeb Ur, et al.
Publicado: (2021)

Protective role of Roflumilast against cadmium-induced cardiotoxicity through inhibition of oxidative stress and NF-κB signaling in rats
por: Ansari, Mohd Nazam, et al.
Publicado: (2019)

Sildenafil Ameliorates Gentamicin-Induced Nephrotoxicity in Rats: Role of iNOS and eNOS
por: Morsy, Mohamed A., et al.
Publicado: (2014)

Role of Oxidative Stress and Inflammatory Cytokines (TNF-α and IL-6) in Acetic Acid-Induced Ulcerative Colitis in Rats: Ameliorated by Otostegia fruticosa
por: Ansari, Mohd Nazam, et al.
Publicado: (2021)

Evaluation of bronchodialatory and antimicrobial activities of Otostegia fruticosa: A multi-mechanistic approach
por: Ansari, Mohd Nazam, et al.
Publicado: (2020)

Mesenchymal Stem Cells Attenuate Cisplatin-Induced Nephrotoxicity in iNOS-Dependent Manner
por: Simovic Markovic, Bojana, et al.
Publicado: (2017)

Effect of Roflumilast in airways disorders via dual inhibition of phosphodiesterase and Ca(2+)-channel
por: Imam, Faisal, et al.
Publicado: (2020)

Antibacterial activity of essential oils from Ethiopian thyme (Thymus serrulatus and Thymus schimperi) against tooth decay bacteria
por: Damtie, Destaw, et al.
Publicado: (2020)

Diuretic activity of the aqueous crude extract and solvent fractions of the leaves of Thymus serrulatus in mice
por: Melka, Amelework Eshetu, et al.
Publicado: (2016)

In Silico, Ex Vivo and In Vivo Studies of Roflumilast as a Potential Antidiarrheal and Antispasmodic agent: Inhibition of the PDE-4 Enzyme and Voltage-gated Ca++ ion Channels
por: Rehman, Najeeb Ur, et al.
Publicado: (2020)

Obesity-Induced Coronary Microvascular Disease Is Prevented by iNOS Deletion and Reversed by iNOS Inhibition
por: Shah, Soham A., et al.
Publicado: (2023)

The dual role of iNOS in cancer()
por: Vannini, Federica, et al.
Publicado: (2015)

In Silico and Ex Vivo Studies on the Spasmolytic Activities of Fenchone Using Isolated Guinea Pig Trachea
por: Rehman, Najeeb Ur, et al.
Publicado: (2022)

GC–MS Analysis and In Vivo and Ex Vivo Antidiarrheal and Antispasmodic Effects of the Methanolic Extract of Acacia nilotica
por: Rehman, Najeeb Ur, et al.
Publicado: (2022)

The Detailed Pharmacodynamics of the Gut Relaxant Effect and GC-MS Analysis of the Grewia tenax Fruit Extract: In Vivo and Ex Vivo Approach
por: Rehman, Najeeb Ur, et al.
Publicado: (2022)

Chemical Composition, Antioxidant Potential, and Blood Glucose Lowering Effect of Aqueous Extract and Essential Oil of Thymus Serrulatus Hochst. Ex Benth
por: Haile, Tesfay, et al.
Publicado: (2021)

SKLB023 as an iNOS inhibitor alleviated liver fibrosis by inhibiting the TGF-beta/Smad signaling pathway
por: Zhang, Jinhang, et al.
Publicado: (2018)

IFNγ and iNOS-Mediated Alterations in the Bone Marrow and Thymus and Its Impact on Mycobacterium avium-Induced Thymic Atrophy
por: Barreira-Silva, Palmira, et al.
Publicado: (2021)

Effects of Essential Oils of Elettaria cardamomum Grown in India and Guatemala on Gram-Negative Bacteria and Gastrointestinal Disorders
por: Alam, Aftab, et al.
Publicado: (2021)

Dual Inhibition of Phosphodiesterase and Ca(++) Channels Explains the Medicinal Use of Balanites aegyptiaca (L.) in Hyperactive Gut Disorders
por: Rehman, Najeeb Ur, et al.
Publicado: (2022)

Brain function in iNOS knock out or iNOS inhibited (l-NIL) mice under endotoxic shock
por: Schweighöfer, Hanna, et al.
Publicado: (2014)

The expressions of AMACR and iNOS in prostate adenocarcinomas
por: Ozgur, Tumay, et al.
Publicado: (2013)

Targeting iNOS to increase efficacy of immunotherapies
por: Ekmekcioglu, Suhendan, et al.
Publicado: (2017)

Downregulation of iNOS/NO Promotes Epithelial–Mesenchymal Transition and Metastasis in Colorectal Cancer
por: Du, Qiang, et al.
Publicado: (2023)

SMAD3 Deficiency Promotes Inflammatory Aortic Aneurysms in Angiotensin II–Infused Mice Via Activation of iNOS
por: Tan, Chek K., et al.
Publicado: (2013)

Crisaborole Loaded Nanoemulsion Based Chitosan Gel: Formulation, Physicochemical Characterization and Wound Healing Studies
por: Ansari, Mohd Nazam, et al.
Publicado: (2022)

Upregulation of iNOS and phosphorylated eNOS in the implantation‐induced blastocysts of mice
por: Seki, Misato, et al.
Publicado: (2023)

iNOS polymorphism modulates iNOS/NO expression via impaired antioxidant and ROS content in P. vivax and P. falciparum infection
por: Kumar, Amod, et al.
Publicado: (2017)

Cadmium Transporters in the Kidney and Cadmium-Induced Nephrotoxicity
por: Yang, Hong, et al.
Publicado: (2015)

Aging and Insulin Resistance: Just Say iNOS
por: Evans, Joseph L., et al.
Publicado: (2013)

Recipient iNOS but Not eNOS Deficiency Reduces Luminal Narrowing in Tracheal Allografts
por: Minamoto, Kanji, et al.
Publicado: (2002)

The return of the Scarlet Pimpernel: cobalamin in inflammation II — cobalamins can both selectively promote all three nitric oxide synthases (NOS), particularly iNOS and eNOS, and, as needed, selectively inhibit iNOS and nNOS
por: Wheatley, Carmen
Publicado: (2007)

Perthamide C Inhibits eNOS and iNOS Expression and Has Immunomodulating Activity In Vivo
por: Bucci, Mariarosaria, et al.
Publicado: (2013)

eNOS/iNOS and endoplasmic reticulum stress-induced apoptosis in the placentas of patients with preeclampsia
por: Du, L, et al.
Publicado: (2017)

The role of tumour-derived iNOS in tumour progression and angiogenesis
por: Kostourou, V, et al.
Publicado: (2011)

Inhibition of Inflammation and iNOS Improves Lymphatic Function in Obesity
por: Torrisi, Jeremy S., et al.
Publicado: (2016)

Regulation of iNOS on Immune Cells and Its Role in Diseases
por: Xue, Qingjie, et al.
Publicado: (2018)

Hepatic Lysosomal iNOS Activity Impairs Autophagy in Obesity
por: Qian, Qingwen, et al.
Publicado: (2019)

The Potential Role of iNOS in Ovarian Cancer Progression and Chemoresistance
por: Kielbik, Michal, et al.
Publicado: (2019)

Macrophage Reprogramming and Cancer Therapeutics: Role of iNOS-Derived NO
por: Kashfi, Khosrow, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_a2lfqmh8dpfjruh3fi8p73n1v5