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COVID-19 and the Kidney: A Worrisome Scenario of Acute and Chronic Consequences
Acute kidney injury (AKI) is a common finding in patients with coronavirus disease 2019 (COVID-19) and has been associated with higher rates of death when compared to COVID-19 patients without kidney injury. Whereas the definitive pathogenesis of COVID-19-related AKI (CoV-AKI) is not clear, histopat...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956338/ https://www.ncbi.nlm.nih.gov/pubmed/33668833 http://dx.doi.org/10.3390/jcm10050900 |
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author | Sanchez-Russo, Luis Billah, Marzuq Chancay, Jorge Hindi, Judy Cravedi, Paolo |
author_facet | Sanchez-Russo, Luis Billah, Marzuq Chancay, Jorge Hindi, Judy Cravedi, Paolo |
author_sort | Sanchez-Russo, Luis |
collection | PubMed |
description | Acute kidney injury (AKI) is a common finding in patients with coronavirus disease 2019 (COVID-19) and has been associated with higher rates of death when compared to COVID-19 patients without kidney injury. Whereas the definitive pathogenesis of COVID-19-related AKI (CoV-AKI) is not clear, histopathologic evidence seems to point at multiple etiologies for the disease, including indirect and direct viral kidney injury. The high incidence of CoV-AKI, along with the aggressive clinical presentation of this entity, have increased the demands for kidney replacement therapies, rapidly overwhelming the supplies of healthcare systems even in major tertiary care centers. As a result, nephrologists have come up with alternatives to maximize the efficiency of treatments and have developed non-conventional therapeutic alternatives such as the implementation of acute peritoneal dialysis for critically ill patients. The long-term implications of CoV-AKI are yet unknown, though early studies suggest that around one third of the patients who survive will remain dependent on kidney replacement therapy. Nephrologists and healthcare workers need to be familiar with the clinical presentation and therapeutic challenges of CoV-AKI in order to develop strategies to mitigate the burden of the disease for patients, and for services providing kidney replacement therapies. |
format | Online Article Text |
id | pubmed-7956338 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79563382021-03-15 COVID-19 and the Kidney: A Worrisome Scenario of Acute and Chronic Consequences Sanchez-Russo, Luis Billah, Marzuq Chancay, Jorge Hindi, Judy Cravedi, Paolo J Clin Med Review Acute kidney injury (AKI) is a common finding in patients with coronavirus disease 2019 (COVID-19) and has been associated with higher rates of death when compared to COVID-19 patients without kidney injury. Whereas the definitive pathogenesis of COVID-19-related AKI (CoV-AKI) is not clear, histopathologic evidence seems to point at multiple etiologies for the disease, including indirect and direct viral kidney injury. The high incidence of CoV-AKI, along with the aggressive clinical presentation of this entity, have increased the demands for kidney replacement therapies, rapidly overwhelming the supplies of healthcare systems even in major tertiary care centers. As a result, nephrologists have come up with alternatives to maximize the efficiency of treatments and have developed non-conventional therapeutic alternatives such as the implementation of acute peritoneal dialysis for critically ill patients. The long-term implications of CoV-AKI are yet unknown, though early studies suggest that around one third of the patients who survive will remain dependent on kidney replacement therapy. Nephrologists and healthcare workers need to be familiar with the clinical presentation and therapeutic challenges of CoV-AKI in order to develop strategies to mitigate the burden of the disease for patients, and for services providing kidney replacement therapies. MDPI 2021-02-25 /pmc/articles/PMC7956338/ /pubmed/33668833 http://dx.doi.org/10.3390/jcm10050900 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sanchez-Russo, Luis Billah, Marzuq Chancay, Jorge Hindi, Judy Cravedi, Paolo COVID-19 and the Kidney: A Worrisome Scenario of Acute and Chronic Consequences |
title | COVID-19 and the Kidney: A Worrisome Scenario of Acute and Chronic Consequences |
title_full | COVID-19 and the Kidney: A Worrisome Scenario of Acute and Chronic Consequences |
title_fullStr | COVID-19 and the Kidney: A Worrisome Scenario of Acute and Chronic Consequences |
title_full_unstemmed | COVID-19 and the Kidney: A Worrisome Scenario of Acute and Chronic Consequences |
title_short | COVID-19 and the Kidney: A Worrisome Scenario of Acute and Chronic Consequences |
title_sort | covid-19 and the kidney: a worrisome scenario of acute and chronic consequences |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956338/ https://www.ncbi.nlm.nih.gov/pubmed/33668833 http://dx.doi.org/10.3390/jcm10050900 |
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