A Role for Human DNA Polymerase λ in Alternative Lengthening of Telomeres

Telomerase negative cancer cell types use the Alternative Lengthening of Telomeres (ALT) pathway to elongate telomeres ends. Here, we show that silencing human DNA polymerase (Pol λ) in ALT cells represses ALT activity and induces telomeric stress. In addition, replication stress in the absence of P...

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Detalles Bibliográficos
Autores principales: Mentegari, Elisa, Bertoletti, Federica, Kissova, Miroslava, Zucca, Elisa, Galli, Silvia, Tagliavini, Giulia, Garbelli, Anna, Maffia, Antonio, Bione, Silvia, Ferrari, Elena, d’Adda di Fagagna, Fabrizio, Francia, Sofia, Sabbioneda, Simone, Chen, Liuh-Yow, Lingner, Joachim, Bergoglio, Valerie, Hoffmann, Jean-Sébastien, Hübscher, Ulrich, Crespan, Emmanuele, Maga, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956399/
https://www.ncbi.nlm.nih.gov/pubmed/33673424
http://dx.doi.org/10.3390/ijms22052365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956399/
https://www.ncbi.nlm.nih.gov/pubmed/33673424
http://dx.doi.org/10.3390/ijms22052365

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