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HIF-Prolyl Hydroxylase Domain Proteins (PHDs) in Cancer—Potential Targets for Anti-Tumor Therapy?

SIMPLE SUMMARY: In solid tumors, proliferation of cancer cells typically outpaces the growth of functional vessels. The net result is often an obstructed blood circulation and areas of deprived oxygen (hypoxia). To overcome this acute stress, hypoxia inducible factors (HIFs) stimulate the expression...

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Detalles Bibliográficos
Autores principales:	Gaete, Diana, Rodriguez, Diego, Watts, Deepika, Sormendi, Sundary, Chavakis, Triantafyllos, Wielockx, Ben
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956578/ https://www.ncbi.nlm.nih.gov/pubmed/33673417 http://dx.doi.org/10.3390/cancers13050988

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