Cargando…

Identification and Validation of ERK5 as a DNA Damage Modulating Drug Target in Glioblastoma

SIMPLE SUMMARY: Glioblastomas are high-grade brain tumours and are the most common form of malignancy arising in the brain. Patient survival has improved little over the last 40 years, highlighting an urgent unmet need for more effective treatments for these tumours. Current standard-of-care treatme...

Descripción completa

Detalles Bibliográficos
Autores principales:	Carmell, Natasha, Rominiyi, Ola, Myers, Katie N., McGarrity-Cottrell, Connor, Vanderlinden, Aurelie, Lad, Nikita, Perroux-David, Eva, El-Khamisy, Sherif F., Fernando, Malee, Finegan, Katherine G., Brown, Stephen, Collis, Spencer J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956595/ https://www.ncbi.nlm.nih.gov/pubmed/33668183 http://dx.doi.org/10.3390/cancers13050944

Ejemplares similares

Ex-vivo drug screening of surgically resected glioma stem cells to replace murine avatars and provide personalise cancer therapy for glioblastoma patients
por: Gagg, Hannah, et al.
Publicado: (2023)

DNA damage response inhibitors enhance tumour treating fields (TTFields) potency in glioma stem-like cells
por: Vanderlinden, Aurelie, et al.
Publicado: (2023)

Tumour treating fields therapy for glioblastoma: current advances and future directions
por: Rominiyi, Ola, et al.
Publicado: (2020)

Correction: Tumour treating fields therapy for glioblastoma: current advances and future directions
por: Rominiyi, Ola, et al.
Publicado: (2021)

DDRugging glioblastoma: understanding and targeting the DNA damage response to improve future therapies
por: Rominiyi, Ola, et al.
Publicado: (2021)

The ‘Ins and Outs’ of Early Preclinical Models for Brain Tumor Research: Are They Valuable and Have We Been Doing It Wrong?
por: Rominiyi, Ola, et al.
Publicado: (2019)

The relationship of CDK18 expression in breast cancer to clinicopathological parameters and therapeutic response
por: Barone, Giancarlo, et al.
Publicado: (2018)

Precision oncology using ex vivo technology: a step towards individualised cancer care?
por: Williams, Sophie T., et al.
Publicado: (2022)

Spiroplasma taxonomy and identification of the sex ratio organisms: can they be cultivated?
por: Williamson, D. L., et al.
Publicado: (1983)

Screening for Familial Colorectal Cancer Risk amongst Colonoscopy Patients New to an Open-Access Endoscopy Center
por: Moole, Sumana, et al.
Publicado: (2012)

Analysis of spiroplasma proteins: contribution to the taxonomy of group IV spiroplasmas and the characterization of spiroplasma protein antigens.
por: Mouches, C., et al.
Publicado: (1983)

The effect of metabolic stress on genome stability of a synthetic biology chassis Escherichia coli K12 strain
por: Couto, Jillian M., et al.
Publicado: (2018)

FANCD2 re-expression is associated with glioma grade and chemical inhibition of the Fanconi Anaemia pathway sensitises gliomas to chemotherapeutic agents
por: Patil, Abhijit A., et al.
Publicado: (2014)

Improvement in quality of life measures in patients with refractory hepatitis C, responding to re-treatment with Pegylated interferon alpha -2b and ribavirin
por: Mathew, Abraham, et al.
Publicado: (2006)

Barrett's Esophagus: Emerging Knowledge and Management Strategies
por: Bhardwaj, Atul, et al.
Publicado: (2012)

Gastroenterologist focus of clinical practice affects adenoma detection in screening colonoscopy
por: Razjouyan, Hadie, et al.
Publicado: (2023)

Silicon Carbide-Based DNA Sensing Technologies
por: Mamun, Abdulla Al, et al.
Publicado: (2023)

Understanding the Causes and Implications of Endothelial Metabolic Variation in Cardiovascular Disease through Genome-Scale Metabolic Modeling
por: McGarrity, Sarah, et al.
Publicado: (2016)

Current Status and Future Prospects of Genome-Scale Metabolic Modeling to Optimize the Use of Mesenchymal Stem Cells in Regenerative Medicine
por: Sigmarsdóttir, Þóra, et al.
Publicado: (2020)

Colonic Intussusception Secondary to Hereditary Angioedema
por: Roy, Justin, et al.
Publicado: (2021)

Analyzing Metabolic States of Adipogenic and Osteogenic Differentiation in Human Mesenchymal Stem Cells via Genome Scale Metabolic Model Reconstruction
por: Sigmarsdottir, Thora Bjorg, et al.
Publicado: (2021)

To live or to die: a matter of processing damaged DNA termini in neurons
por: El-Khamisy, Sherif F
Publicado: (2011)

The essentiality of folate for the maintenance of deoxynucleotide precursor pools, DNA synthesis, and cell cycle progression in PHA-stimulated lymphocytes.
por: James, S J, et al.
Publicado: (1993)

Liquid chromatography–mass spectrometry for measuring deoxythioguanosine in DNA from thiopurine-treated patients
por: Coulthard, Sally A., et al.
Publicado: (2016)

Perturbed autophagy and DNA repair converge to promote neurodegeneration in amyotrophic lateral sclerosis and dementia
por: Walker, Callum, et al.
Publicado: (2018)

In-Frame Amber Stop Codon Replacement Mutagenesis for the Directed Evolution of Proteins Containing Non-Canonical Amino Acids: Identification of Residues Open to Bio-Orthogonal Modification
por: Arpino, James A. J., et al.
Publicado: (2015)

Azathioprine with Allopurinol: Lower Deoxythioguanosine in DNA and Transcriptome Changes Indicate Mechanistic Differences to Azathioprine Alone
por: Coulthard, Sally A., et al.
Publicado: (2017)

The effect of narrative element incorporation on physical activity and game experience in active and sedentary virtual reality games
por: Lu, Amy Shirong, et al.
Publicado: (2023)

The revised Bethesda guidelines: extent of utilization in a university hospital medical center with a cancer genetics program
por: Mukherjee, Aparna, et al.
Publicado: (2010)

Percutaneous debridement and washout of walled-off abdominal abscess and necrosis using flexible endoscopy: a large single-center experience
por: Mathers, Bradley, et al.
Publicado: (2016)

Imaging timing after glioblastoma surgery (INTERVAL-GB): protocol for a UK and Ireland, multicentre retrospective cohort study
por: Gillespie, Conor S, et al.
Publicado: (2022)

Findings from the Peutz-Jeghers Syndrome Registry of Uruguay
por: Tchekmedyian, Asadur, et al.
Publicado: (2013)

Ratlas-LH: An MRI template of the Lister hooded rat brain with stereotaxic coordinates for neurosurgical implantations
por: Prior, Malcolm J. W., et al.
Publicado: (2021)

TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy
por: Alagoz, Meryem, et al.
Publicado: (2014)

DNA Homeostasis and Senescence: Lessons from the Naked Mole Rat
por: Boughey, Harvey, et al.
Publicado: (2021)

Editorial: Genomic Instability and Neurodegeneration
por: Fuchs, Julia, et al.
Publicado: (2022)

The critical role of ERK in death resistance and invasiveness of hypoxia-selected glioblastoma cells
por: Kim, Jee-Youn, et al.
Publicado: (2009)

Berberine inhibits angiogenesis in glioblastoma xenografts by targeting the VEGFR2/ERK pathway
por: Jin, Fa, et al.
Publicado: (2019)

ERK1/2 signaling regulates the immune microenvironment and macrophage recruitment in glioblastoma
por: Lailler, Claire, et al.
Publicado: (2019)

Development of a Personalised Device for Systemic Magnetic Drug Targeting to Brain Tumours
por: Patel, Priya, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_gp4c3t4d625j07fvpilsn4rta0