Cargando…

Rabdosianone I, a Bitter Diterpene from an Oriental Herb, Suppresses Thymidylate Synthase Expression by Directly Binding to ANT2 and PHB2

SIMPLE SUMMARY: In the present study, we found the novel pleiotropic regulation of the oncogene product thymidylate synthase (TS) by a chemical biology approach to identify rabdosianone I-binding proteins. Rabdosianone I, which is extracted from a traditional Asian herb Isodon japonicus Hara for lon...

Descripción completa

Detalles Bibliográficos
Autores principales:	Watanabe, Motoki, Yamada, Yasumasa, Kurumida, Yoichi, Kameda, Tomoshi, Sukeno, Mamiko, Iizuka-Ohashi, Mahiro, Sowa, Yoshihiro, Iizumi, Yosuke, Takakura, Hideki, Miyamoto, Shingo, Sakai, Toshiyuki, Mutoh, Michihiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956614/ https://www.ncbi.nlm.nih.gov/pubmed/33652782 http://dx.doi.org/10.3390/cancers13050982

Ejemplares similares

A chemoproteoinformatics approach demonstrates that aspirin increases sensitivity to MEK inhibition by directly binding to RPS5
por: Watanabe, Motoki, et al.
Publicado: (2022)

Stabilization of CDK6 by ribosomal protein uS7, a target protein of the natural product fucoxanthinol
por: Iizumi, Yosuke, et al.
Publicado: (2022)

Deactivation of Glutaminolysis Sensitizes PIK3CA-Mutated Colorectal Cancer Cells to Aspirin-Induced Growth Inhibition
por: Boku, Shogen, et al.
Publicado: (2020)

Blockage of the mevalonate pathway overcomes the apoptotic resistance to MEK inhibitors with suppressing the activation of Akt in cancer cells
por: Iizuka-Ohashi, Mahiro, et al.
Publicado: (2018)

The pleiotropic regulation of cyclin D1 by newly identified sesaminol-binding protein ANT2
por: Watanabe, M, et al.
Publicado: (2017)

Neurobiological Promises of the Bitter Diterpene Lactone Andrographolide
por: Hossain, Rajib, et al.
Publicado: (2022)

Citrus limonL.-Derived Nanovesicles Show an Inhibitory Effect on Cell Growth in p53-Inactivated Colorectal Cancer Cells via the Macropinocytosis Pathway
por: Takakura, Hideki, et al.
Publicado: (2022)

Induction of MYCN-amplified neuroblastoma differentiation through NMYC suppression using PPAR-γ antagonist
por: Nakao-Ise, Yukako, et al.
Publicado: (2023)

Predicting antibody affinity changes upon mutations by combining multiple predictors
por: Kurumida, Yoichi, et al.
Publicado: (2020)

Sodium salicylate and 5-aminosalicylic acid synergistically inhibit the growth of human colon cancer cells and mouse intestinal polyp-derived cells
por: Takakura, Hideki, et al.
Publicado: (2022)

Expression of thymidylate synthase and orotate phosphoribosyltransferase in thymic carcinoma
por: YOKOTA, KEISUKE, et al.
Publicado: (2012)

Examination of PHB Depolymerases in Ralstonia eutropha: Further Elucidation of the Roles of Enzymes in PHB Homeostasis
por: Brigham, Christopher J, et al.
Publicado: (2012)

A Closer Look on the Polyhydroxybutyrate- (PHB-) Negative Phenotype of Ralstonia eutropha PHB(-)4
por: Raberg, Matthias, et al.
Publicado: (2014)

Novel Extracellular PHB Depolymerase from Streptomyces ascomycinicus: PHB Copolymers Degradation in Acidic Conditions
por: García-Hidalgo, Javier, et al.
Publicado: (2013)

xCT Inhibition Increases Sensitivity to Vorinostat in a ROS-Dependent Manner
por: Miyamoto, Keiko, et al.
Publicado: (2020)

Cytotoxic Labdane Diterpenes, Norlabdane Diterpenes and Bis-Labdanic Diterpenes from the Zingiberaceae: A Systematic Review
por: Voon, Kelvin Jianmin, et al.
Publicado: (2022)

Importance of sessile serrated lesions in a patient with familial adenomatous polyposis
por: Watanabe, Motoki, et al.
Publicado: (2021)

Effect of Hammerhead Ribozyme against Human Thymidylate Synthase on the Cytotoxicity of Thymidylate Synthase Inhibitors
por: Kobayashi, Hiroyuki, et al.
Publicado: (1995)

PLA/PHB Blends: Biocompatibilizer Effects
por: D’Anna, Alessandra, et al.
Publicado: (2019)

The Growth of 3T3 Fibroblasts on PHB, PLA and PHB/PLA Blend Films at Different Stages of Their Biodegradation In Vitro
por: Zhuikov, Vsevolod A., et al.
Publicado: (2020)

Exploiting the Physicochemical and Antimicrobial Properties of PHB/PEG and PHB/PEG/ALG-e Blends Loaded with Ag Nanoparticles
por: da Silva, Mário R. P., et al.
Publicado: (2022)

A revision of the “African Non-Spiny” Clade of Solanum L. (Solanum sections Afrosolanum Bitter, Benderianum Bitter, Lemurisolanum Bitter, Lyciosolanum Bitter, Macronesiotes Bitter, and Quadrangulare Bitter: Solanaceae)
por: Knapp, Sandra, et al.
Publicado: (2016)

Phase separation by biopolymers: Basics and applications
por: Kitahara, Ryo, et al.
Publicado: (2022)

An Unusual Diterpene—Enhygromic Acid and Deoxyenhygrolides from a Marine Myxobacterium, Enhygromyxa sp.
por: Tomura, Tomohiko, et al.
Publicado: (2017)

Sex Differences in the Bitterness Perception of an Aromatic Myrtle Bitter Liqueur and Bitter Compounds
por: Rosa, Antonella, et al.
Publicado: (2023)

Stemarane Diterpenes and Diterpenoids †
por: Leonelli, Francesca, et al.
Publicado: (2019)

Experimental Researches on Influence of Bitter Herbs on the Function of the Sound and Diseased Stomach
Publicado: (1890)

Trichinella pseudospiralis vs. T. spiralis thymidylate synthase gene structure and T. pseudospiralis thymidylate synthase retrogene sequence
por: Jagielska, Elżbieta, et al.
Publicado: (2014)

BitterDB: a database of bitter compounds
por: Wiener, Ayana, et al.
Publicado: (2012)

Cyanobacterial Polyhydroxybutyrate (PHB): Screening, Optimization and Characterization
por: Ansari, Sabbir, et al.
Publicado: (2016)

Drug Release Kinetics of Electrospun PHB Meshes
por: Kundrat, Vojtech, et al.
Publicado: (2019)

PHB production from cellobiose with Saccharomyces cerevisiae
por: Ylinen, Anna, et al.
Publicado: (2022)

Prohibitin (PHB) expression is associated with aggressiveness in DLBCL and flavagline-mediated inhibition of cytoplasmic PHB functions induces anti-tumor effects
por: Bentayeb, Hafidha, et al.
Publicado: (2019)

Finding a Benign Plasticizer to Enhance the Microbial Degradation of Polyhydroxybutyrate (PHB) Evaluated by PHB Degrader Microbulbifer sp. SOL66
por: Cho, Jang Yeon, et al.
Publicado: (2022)

An Inhibitory Sex Pheromone Tastes Bitter for Drosophila Males
por: Lacaille, Fabien, et al.
Publicado: (2007)

Functional Characterization of Three Diterpene Synthases Responsible for Tetracyclic Diterpene Biosynthesis in Scoparia dulcis
por: Lee, Jung-Bum, et al.
Publicado: (2022)

Conservation and Role of Electrostatics in Thymidylate Synthase
por: Garg, Divita, et al.
Publicado: (2015)

Identification and characterization of PhbF: A DNA binding protein with regulatory role in the PHB metabolism of Herbaspirillum seropedicae SmR1
por: Kadowaki, Marco AS, et al.
Publicado: (2011)

An Overview of Biotransformation and Toxicity of Diterpenes
por: de Sousa, Ingrid P., et al.
Publicado: (2018)

Total Synthesis of the Diterpene Waihoensene
por: Rosenbaum, Lisa‐Catherine, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_rbefko81usq29cgo93jasgkobt