Optimization and Anti-Cancer Properties of Fluoromethylketones as Covalent Inhibitors for Ubiquitin C-Terminal Hydrolase L1

The deubiquitinating enzyme (DUB) UCHL1 is implicated in various disease states including neurodegenerative disease and cancer. However, there is a lack of quality probe molecules to gain a better understanding on UCHL1 biology. To this end a study was carried out to fully characterize and optimize...

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Detalles Bibliográficos
Autores principales: Krabill, Aaron D., Chen, Hao, Hussain, Sajjad, Hewitt, Chad S., Imhoff, Ryan D., Muli, Christine S., Das, Chittaranjan, Galardy, Paul J., Wendt, Michael K., Flaherty, Daniel P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956625/
https://www.ncbi.nlm.nih.gov/pubmed/33668938
http://dx.doi.org/10.3390/molecules26051227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956625/
https://www.ncbi.nlm.nih.gov/pubmed/33668938
http://dx.doi.org/10.3390/molecules26051227

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