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Cardiovascular Autonomic Control, Sleep and Health Related Quality of Life in Systemic Sclerosis

Chronic pain and dysautonomic symptoms deteriorate Systemic sclerosis (SSc) patients’ health-related quality of life with serious repercussions on social life and even on sleep. Heart Rate Variability (HRV) analysis can identify cardiovascular autonomic control impairment in subclinical condition. T...

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Autores principales: Carandina, Angelica, Bellocchi, Chiara, Dias Rodrigues, Gabriel, Beretta, Lorenzo, Montano, Nicola, Tobaldini, Eleonora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956693/
https://www.ncbi.nlm.nih.gov/pubmed/33668942
http://dx.doi.org/10.3390/ijerph18052276
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author Carandina, Angelica
Bellocchi, Chiara
Dias Rodrigues, Gabriel
Beretta, Lorenzo
Montano, Nicola
Tobaldini, Eleonora
author_facet Carandina, Angelica
Bellocchi, Chiara
Dias Rodrigues, Gabriel
Beretta, Lorenzo
Montano, Nicola
Tobaldini, Eleonora
author_sort Carandina, Angelica
collection PubMed
description Chronic pain and dysautonomic symptoms deteriorate Systemic sclerosis (SSc) patients’ health-related quality of life with serious repercussions on social life and even on sleep. Heart Rate Variability (HRV) analysis can identify cardiovascular autonomic control impairment in subclinical condition. The aim of the present observational cross-sectional study was to assess the relationship between dysautonomic symptoms, quality of life status and cardiovascular autonomic profile. ECG and respiration were recorded at rest in 20 SSc patients. HRV analysis was performed using two different approaches: Linear spectral analysis and non-linear symbolic analysis. Pain was evaluated using the Numeric Rating Scale (NRS) and 3 questionnaires were administered for the evaluation of sleep quality (PSQI), mood tone (PHQ-9) and disability (HAQ). We found that sleep impairment was related to sympathetic predominance at rest measured as low-frequency/high-frequency ratio (LF/HF) (r = 0.48 and p = 0.033); poorer sleep quality was related to higher pain values (r = 0.48 and p = 0.034) and depressive symptoms (r = 0.82 and p < 0.01); higher pain scores were related to higher cardiovascular vagal modulation and higher disability indexes (r = 0.47 and p = 0.038 & r = 0.55 and p = 0.012, respectively). In conclusion dysautonomia and chronic pain showed a severe impact on sleep quality and disability with a consequent worsening of depressive symptom in our cohort of SSc patients.
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spelling pubmed-79566932021-03-16 Cardiovascular Autonomic Control, Sleep and Health Related Quality of Life in Systemic Sclerosis Carandina, Angelica Bellocchi, Chiara Dias Rodrigues, Gabriel Beretta, Lorenzo Montano, Nicola Tobaldini, Eleonora Int J Environ Res Public Health Article Chronic pain and dysautonomic symptoms deteriorate Systemic sclerosis (SSc) patients’ health-related quality of life with serious repercussions on social life and even on sleep. Heart Rate Variability (HRV) analysis can identify cardiovascular autonomic control impairment in subclinical condition. The aim of the present observational cross-sectional study was to assess the relationship between dysautonomic symptoms, quality of life status and cardiovascular autonomic profile. ECG and respiration were recorded at rest in 20 SSc patients. HRV analysis was performed using two different approaches: Linear spectral analysis and non-linear symbolic analysis. Pain was evaluated using the Numeric Rating Scale (NRS) and 3 questionnaires were administered for the evaluation of sleep quality (PSQI), mood tone (PHQ-9) and disability (HAQ). We found that sleep impairment was related to sympathetic predominance at rest measured as low-frequency/high-frequency ratio (LF/HF) (r = 0.48 and p = 0.033); poorer sleep quality was related to higher pain values (r = 0.48 and p = 0.034) and depressive symptoms (r = 0.82 and p < 0.01); higher pain scores were related to higher cardiovascular vagal modulation and higher disability indexes (r = 0.47 and p = 0.038 & r = 0.55 and p = 0.012, respectively). In conclusion dysautonomia and chronic pain showed a severe impact on sleep quality and disability with a consequent worsening of depressive symptom in our cohort of SSc patients. MDPI 2021-02-25 2021-03 /pmc/articles/PMC7956693/ /pubmed/33668942 http://dx.doi.org/10.3390/ijerph18052276 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Carandina, Angelica
Bellocchi, Chiara
Dias Rodrigues, Gabriel
Beretta, Lorenzo
Montano, Nicola
Tobaldini, Eleonora
Cardiovascular Autonomic Control, Sleep and Health Related Quality of Life in Systemic Sclerosis
title Cardiovascular Autonomic Control, Sleep and Health Related Quality of Life in Systemic Sclerosis
title_full Cardiovascular Autonomic Control, Sleep and Health Related Quality of Life in Systemic Sclerosis
title_fullStr Cardiovascular Autonomic Control, Sleep and Health Related Quality of Life in Systemic Sclerosis
title_full_unstemmed Cardiovascular Autonomic Control, Sleep and Health Related Quality of Life in Systemic Sclerosis
title_short Cardiovascular Autonomic Control, Sleep and Health Related Quality of Life in Systemic Sclerosis
title_sort cardiovascular autonomic control, sleep and health related quality of life in systemic sclerosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956693/
https://www.ncbi.nlm.nih.gov/pubmed/33668942
http://dx.doi.org/10.3390/ijerph18052276
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