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Thermal Ablation and High-Resolution Imaging Using a Back-to-Back (BTB) Dual-Mode Ultrasonic Transducer: In Vivo Results
We present a back-to-back (BTB) structured, dual-mode ultrasonic device that incorporates a single-element 5.3 MHz transducer for high-intensity focused ultrasound (HIFU) treatment and a single-element 20.0 MHz transducer for high-resolution ultrasound imaging. Ultrasound image-guided surgical syste...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956793/ https://www.ncbi.nlm.nih.gov/pubmed/33668260 http://dx.doi.org/10.3390/s21051580 |
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author | Lim, Hae Gyun Kim, Hyunhee Kim, Kyungmin Park, Jeongwoo Kim, Yeonggeun Yoo, Jinhee Heo, Dasom Baik, Jinhwan Park, Sung-Min Kim, Hyung Ham |
author_facet | Lim, Hae Gyun Kim, Hyunhee Kim, Kyungmin Park, Jeongwoo Kim, Yeonggeun Yoo, Jinhee Heo, Dasom Baik, Jinhwan Park, Sung-Min Kim, Hyung Ham |
author_sort | Lim, Hae Gyun |
collection | PubMed |
description | We present a back-to-back (BTB) structured, dual-mode ultrasonic device that incorporates a single-element 5.3 MHz transducer for high-intensity focused ultrasound (HIFU) treatment and a single-element 20.0 MHz transducer for high-resolution ultrasound imaging. Ultrasound image-guided surgical systems have been developed for lesion monitoring to ensure that ultrasonic treatment is correctly administered at the right locations. In this study, we developed a dual-element transducer composed of two elements that share the same housing but work independently with a BTB structure, enabling a mode change between therapy and imaging via 180-degree mechanical rotation. The optic fibers were embedded in the HIFU focal region of ex vivo chicken breasts and the temperature change was measured. Images were obtained in vivo mice before and after treatment and compared to identify the treated region. We successfully acquired B-mode and C-scan images that display the hyperechoic region indicating coagulation necrosis in the HIFU-treated volume up to a depth of 10 mm. The compact BTB dual-mode ultrasonic transducer may be used for subcutaneous thermal ablation and monitoring, minimally invasive surgery, and other clinical applications, all with ultrasound only. |
format | Online Article Text |
id | pubmed-7956793 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79567932021-03-16 Thermal Ablation and High-Resolution Imaging Using a Back-to-Back (BTB) Dual-Mode Ultrasonic Transducer: In Vivo Results Lim, Hae Gyun Kim, Hyunhee Kim, Kyungmin Park, Jeongwoo Kim, Yeonggeun Yoo, Jinhee Heo, Dasom Baik, Jinhwan Park, Sung-Min Kim, Hyung Ham Sensors (Basel) Article We present a back-to-back (BTB) structured, dual-mode ultrasonic device that incorporates a single-element 5.3 MHz transducer for high-intensity focused ultrasound (HIFU) treatment and a single-element 20.0 MHz transducer for high-resolution ultrasound imaging. Ultrasound image-guided surgical systems have been developed for lesion monitoring to ensure that ultrasonic treatment is correctly administered at the right locations. In this study, we developed a dual-element transducer composed of two elements that share the same housing but work independently with a BTB structure, enabling a mode change between therapy and imaging via 180-degree mechanical rotation. The optic fibers were embedded in the HIFU focal region of ex vivo chicken breasts and the temperature change was measured. Images were obtained in vivo mice before and after treatment and compared to identify the treated region. We successfully acquired B-mode and C-scan images that display the hyperechoic region indicating coagulation necrosis in the HIFU-treated volume up to a depth of 10 mm. The compact BTB dual-mode ultrasonic transducer may be used for subcutaneous thermal ablation and monitoring, minimally invasive surgery, and other clinical applications, all with ultrasound only. MDPI 2021-02-24 /pmc/articles/PMC7956793/ /pubmed/33668260 http://dx.doi.org/10.3390/s21051580 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lim, Hae Gyun Kim, Hyunhee Kim, Kyungmin Park, Jeongwoo Kim, Yeonggeun Yoo, Jinhee Heo, Dasom Baik, Jinhwan Park, Sung-Min Kim, Hyung Ham Thermal Ablation and High-Resolution Imaging Using a Back-to-Back (BTB) Dual-Mode Ultrasonic Transducer: In Vivo Results |
title | Thermal Ablation and High-Resolution Imaging Using a Back-to-Back (BTB) Dual-Mode Ultrasonic Transducer: In Vivo Results |
title_full | Thermal Ablation and High-Resolution Imaging Using a Back-to-Back (BTB) Dual-Mode Ultrasonic Transducer: In Vivo Results |
title_fullStr | Thermal Ablation and High-Resolution Imaging Using a Back-to-Back (BTB) Dual-Mode Ultrasonic Transducer: In Vivo Results |
title_full_unstemmed | Thermal Ablation and High-Resolution Imaging Using a Back-to-Back (BTB) Dual-Mode Ultrasonic Transducer: In Vivo Results |
title_short | Thermal Ablation and High-Resolution Imaging Using a Back-to-Back (BTB) Dual-Mode Ultrasonic Transducer: In Vivo Results |
title_sort | thermal ablation and high-resolution imaging using a back-to-back (btb) dual-mode ultrasonic transducer: in vivo results |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956793/ https://www.ncbi.nlm.nih.gov/pubmed/33668260 http://dx.doi.org/10.3390/s21051580 |
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