Cargando…

Clinicopathological and Molecular Analysis of 45 Cases of Pure Mucinous Breast Cancer

Pure mucinous breast carcinoma (PMBC) is characterized by clusters of tumor cells floating in abundant extracellular mucin and can be classified into paucicellular (Type A) and hypercellular (Type B) subtypes. However, the clinicopathological and genomic differences between these two subtypes have n...

Descripción completa

Detalles Bibliográficos
Autores principales: Yim, Hyun Ee, Kim, Jang-Hee, Ahn, Mi Sun, Jung, Yongsik, Roh, Jin, Park, So Hyun, Kim, Tae-Gyu, Choi, Jin-Hyuk, Kang, Seok Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956951/
https://www.ncbi.nlm.nih.gov/pubmed/33732635
http://dx.doi.org/10.3389/fonc.2020.558760
_version_ 1783664550186319872
author Yim, Hyun Ee
Kim, Jang-Hee
Ahn, Mi Sun
Jung, Yongsik
Roh, Jin
Park, So Hyun
Kim, Tae-Gyu
Choi, Jin-Hyuk
Kang, Seok Yun
author_facet Yim, Hyun Ee
Kim, Jang-Hee
Ahn, Mi Sun
Jung, Yongsik
Roh, Jin
Park, So Hyun
Kim, Tae-Gyu
Choi, Jin-Hyuk
Kang, Seok Yun
author_sort Yim, Hyun Ee
collection PubMed
description Pure mucinous breast carcinoma (PMBC) is characterized by clusters of tumor cells floating in abundant extracellular mucin and can be classified into paucicellular (Type A) and hypercellular (Type B) subtypes. However, the clinicopathological and genomic differences between these two subtypes have not been well characterized. We retrospectively investigated the clinicopathologic features of 45 cases of surgically removed PMBC (31 Type A and 14 Type B). We also performed whole-exome sequencing (WES) in eight cases of PMBC. We found that Type B PMBC occurs at an older age and shows more aggressive clinical behavior than Type A. WES analysis revealed that HYDIN was the most frequently mutated gene in both types of PMBC. Although Type B PMBC showed a tendency toward more frequent genetic alterations, there were no statistically significant differences between the two subtypes in single nucleotide variants or insertions or deletions of bases associated with moderate or high effects. Our results provide additional evidence that PMBCs are clinicopathologically and genetically heterogeneous and lack pathognomonic genetic alterations. Further, Type B PMBC is more frequently associated with lymph node metastasis than Type A.
format Online
Article
Text
id pubmed-7956951
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-79569512021-03-16 Clinicopathological and Molecular Analysis of 45 Cases of Pure Mucinous Breast Cancer Yim, Hyun Ee Kim, Jang-Hee Ahn, Mi Sun Jung, Yongsik Roh, Jin Park, So Hyun Kim, Tae-Gyu Choi, Jin-Hyuk Kang, Seok Yun Front Oncol Oncology Pure mucinous breast carcinoma (PMBC) is characterized by clusters of tumor cells floating in abundant extracellular mucin and can be classified into paucicellular (Type A) and hypercellular (Type B) subtypes. However, the clinicopathological and genomic differences between these two subtypes have not been well characterized. We retrospectively investigated the clinicopathologic features of 45 cases of surgically removed PMBC (31 Type A and 14 Type B). We also performed whole-exome sequencing (WES) in eight cases of PMBC. We found that Type B PMBC occurs at an older age and shows more aggressive clinical behavior than Type A. WES analysis revealed that HYDIN was the most frequently mutated gene in both types of PMBC. Although Type B PMBC showed a tendency toward more frequent genetic alterations, there were no statistically significant differences between the two subtypes in single nucleotide variants or insertions or deletions of bases associated with moderate or high effects. Our results provide additional evidence that PMBCs are clinicopathologically and genetically heterogeneous and lack pathognomonic genetic alterations. Further, Type B PMBC is more frequently associated with lymph node metastasis than Type A. Frontiers Media S.A. 2021-03-01 /pmc/articles/PMC7956951/ /pubmed/33732635 http://dx.doi.org/10.3389/fonc.2020.558760 Text en Copyright © 2021 Yim, Kim, Ahn, Jung, Roh, Park, Kim, Choi and Kang http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Yim, Hyun Ee
Kim, Jang-Hee
Ahn, Mi Sun
Jung, Yongsik
Roh, Jin
Park, So Hyun
Kim, Tae-Gyu
Choi, Jin-Hyuk
Kang, Seok Yun
Clinicopathological and Molecular Analysis of 45 Cases of Pure Mucinous Breast Cancer
title Clinicopathological and Molecular Analysis of 45 Cases of Pure Mucinous Breast Cancer
title_full Clinicopathological and Molecular Analysis of 45 Cases of Pure Mucinous Breast Cancer
title_fullStr Clinicopathological and Molecular Analysis of 45 Cases of Pure Mucinous Breast Cancer
title_full_unstemmed Clinicopathological and Molecular Analysis of 45 Cases of Pure Mucinous Breast Cancer
title_short Clinicopathological and Molecular Analysis of 45 Cases of Pure Mucinous Breast Cancer
title_sort clinicopathological and molecular analysis of 45 cases of pure mucinous breast cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956951/
https://www.ncbi.nlm.nih.gov/pubmed/33732635
http://dx.doi.org/10.3389/fonc.2020.558760
work_keys_str_mv AT yimhyunee clinicopathologicalandmolecularanalysisof45casesofpuremucinousbreastcancer
AT kimjanghee clinicopathologicalandmolecularanalysisof45casesofpuremucinousbreastcancer
AT ahnmisun clinicopathologicalandmolecularanalysisof45casesofpuremucinousbreastcancer
AT jungyongsik clinicopathologicalandmolecularanalysisof45casesofpuremucinousbreastcancer
AT rohjin clinicopathologicalandmolecularanalysisof45casesofpuremucinousbreastcancer
AT parksohyun clinicopathologicalandmolecularanalysisof45casesofpuremucinousbreastcancer
AT kimtaegyu clinicopathologicalandmolecularanalysisof45casesofpuremucinousbreastcancer
AT choijinhyuk clinicopathologicalandmolecularanalysisof45casesofpuremucinousbreastcancer
AT kangseokyun clinicopathologicalandmolecularanalysisof45casesofpuremucinousbreastcancer