Hematopoietic stem cell gene therapy targeting TGFβ enhances the efficacy of irradiation therapy in a preclinical glioblastoma model

Patients with glioblastoma (GBM) have a poor prognosis, and inefficient delivery of drugs to tumors represents a major therapeutic hurdle. Hematopoietic stem cell (HSC)-derived myeloid cells efficiently home to GBM and constitute up to 50% of intratumoral cells, making them highly appropriate therap...

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Detalles Bibliográficos
Autores principales: Andreou, Tereza, Williams, Jennifer, Brownlie, Rebecca J, Salmond, Robert J, Watson, Erica, Shaw, Gary, Melcher, Alan, Wurdak, Heiko, Short, Susan C, Lorger, Mihaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957127/
https://www.ncbi.nlm.nih.gov/pubmed/33707311
http://dx.doi.org/10.1136/jitc-2020-001143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957127/
https://www.ncbi.nlm.nih.gov/pubmed/33707311
http://dx.doi.org/10.1136/jitc-2020-001143

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