Cargando…
Activated Prothrombin Complex Concentrate for coagulopathy reversal secondary to ischemic hepatic injury due to cardiac tamponade: A case report
INTRODUCTION AND IMPORTANCE: Correction of coagulopathy is needed before invasive procedures. However, there is limited evidence to support using Prothrombin Complex Concentrate (PCC) to reverse coagulopathy secondary to liver disease. CASE PRESENTATION: We report a case of a 68-year-old male patien...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957146/ https://www.ncbi.nlm.nih.gov/pubmed/33714001 http://dx.doi.org/10.1016/j.ijscr.2021.105719 |
_version_ | 1783664592034988032 |
---|---|
author | Mitwally, Hassan Rahhal, Alaa Fahmi, Amr Ananthegowda, Dore |
author_facet | Mitwally, Hassan Rahhal, Alaa Fahmi, Amr Ananthegowda, Dore |
author_sort | Mitwally, Hassan |
collection | PubMed |
description | INTRODUCTION AND IMPORTANCE: Correction of coagulopathy is needed before invasive procedures. However, there is limited evidence to support using Prothrombin Complex Concentrate (PCC) to reverse coagulopathy secondary to liver disease. CASE PRESENTATION: We report a case of a 68-year-old male patient a known case of heart failure with preserved ejection fraction, who developed cardiac tamponade, resulting in hemodynamic instability and ischemic liver injury leading to coagulopathy of INR 2.3. Activated PCC (FEIBA) was used to reverse coagulopathy. INR dropped to 1.9 and the procedure was performed uneventfully with successful elimination of tamponade signs evidenced by echocardiography. CLINICAL DISCUSSION: In this case, the patient required an urgent pericardiocentesis. Activated PCC used successfully to reverse coagulopathy, which was important prior to the procedure. CONCLUSION: In view of the need for urgent pericardiocentesis, coagulopathy due to ischemic liver injury could be reversed with the use of activated PCC. |
format | Online Article Text |
id | pubmed-7957146 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-79571462021-03-19 Activated Prothrombin Complex Concentrate for coagulopathy reversal secondary to ischemic hepatic injury due to cardiac tamponade: A case report Mitwally, Hassan Rahhal, Alaa Fahmi, Amr Ananthegowda, Dore Int J Surg Case Rep Case Report INTRODUCTION AND IMPORTANCE: Correction of coagulopathy is needed before invasive procedures. However, there is limited evidence to support using Prothrombin Complex Concentrate (PCC) to reverse coagulopathy secondary to liver disease. CASE PRESENTATION: We report a case of a 68-year-old male patient a known case of heart failure with preserved ejection fraction, who developed cardiac tamponade, resulting in hemodynamic instability and ischemic liver injury leading to coagulopathy of INR 2.3. Activated PCC (FEIBA) was used to reverse coagulopathy. INR dropped to 1.9 and the procedure was performed uneventfully with successful elimination of tamponade signs evidenced by echocardiography. CLINICAL DISCUSSION: In this case, the patient required an urgent pericardiocentesis. Activated PCC used successfully to reverse coagulopathy, which was important prior to the procedure. CONCLUSION: In view of the need for urgent pericardiocentesis, coagulopathy due to ischemic liver injury could be reversed with the use of activated PCC. Elsevier 2021-03-05 /pmc/articles/PMC7957146/ /pubmed/33714001 http://dx.doi.org/10.1016/j.ijscr.2021.105719 Text en © 2021 Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Mitwally, Hassan Rahhal, Alaa Fahmi, Amr Ananthegowda, Dore Activated Prothrombin Complex Concentrate for coagulopathy reversal secondary to ischemic hepatic injury due to cardiac tamponade: A case report |
title | Activated Prothrombin Complex Concentrate for coagulopathy reversal secondary to ischemic hepatic injury due to cardiac tamponade: A case report |
title_full | Activated Prothrombin Complex Concentrate for coagulopathy reversal secondary to ischemic hepatic injury due to cardiac tamponade: A case report |
title_fullStr | Activated Prothrombin Complex Concentrate for coagulopathy reversal secondary to ischemic hepatic injury due to cardiac tamponade: A case report |
title_full_unstemmed | Activated Prothrombin Complex Concentrate for coagulopathy reversal secondary to ischemic hepatic injury due to cardiac tamponade: A case report |
title_short | Activated Prothrombin Complex Concentrate for coagulopathy reversal secondary to ischemic hepatic injury due to cardiac tamponade: A case report |
title_sort | activated prothrombin complex concentrate for coagulopathy reversal secondary to ischemic hepatic injury due to cardiac tamponade: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957146/ https://www.ncbi.nlm.nih.gov/pubmed/33714001 http://dx.doi.org/10.1016/j.ijscr.2021.105719 |
work_keys_str_mv | AT mitwallyhassan activatedprothrombincomplexconcentrateforcoagulopathyreversalsecondarytoischemichepaticinjuryduetocardiactamponadeacasereport AT rahhalalaa activatedprothrombincomplexconcentrateforcoagulopathyreversalsecondarytoischemichepaticinjuryduetocardiactamponadeacasereport AT fahmiamr activatedprothrombincomplexconcentrateforcoagulopathyreversalsecondarytoischemichepaticinjuryduetocardiactamponadeacasereport AT ananthegowdadore activatedprothrombincomplexconcentrateforcoagulopathyreversalsecondarytoischemichepaticinjuryduetocardiactamponadeacasereport |