Serum macrophage inhibitory cytokine‐1 as a clinical marker for non–small cell lung cancer

The aim of this study was to investigate the value of serum macrophage inhibitory factor‐1 (MIC‐1) level in patients with non–small cell lung cancer (NSCLC). Serum samples from 296 patients with NSCLC and 240 healthy controls were collected. The levels of serum MIC‐1 were determined by ELISA. The se...

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Detalles Bibliográficos
Autores principales: Xu, Chunhua, Li, Li, Wang, Wei, Zhang, Qian, Zhang, Xiuwei, Yang, Rusong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957168/
https://www.ncbi.nlm.nih.gov/pubmed/33605059
http://dx.doi.org/10.1111/jcmm.16360
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author Xu, Chunhua
Li, Li
Wang, Wei
Zhang, Qian
Zhang, Xiuwei
Yang, Rusong
author_facet Xu, Chunhua
Li, Li
Wang, Wei
Zhang, Qian
Zhang, Xiuwei
Yang, Rusong
author_sort Xu, Chunhua
collection PubMed
description The aim of this study was to investigate the value of serum macrophage inhibitory factor‐1 (MIC‐1) level in patients with non–small cell lung cancer (NSCLC). Serum samples from 296 patients with NSCLC and 240 healthy controls were collected. The levels of serum MIC‐1 were determined by ELISA. The serum MIC‐1 levels in NSCLC patients were higher than that of the controls (P <.001). Univariate and multivariate Cox regression analysis showed that serum MIC‐1 was an independent prognostic indicator of OS and PFS. Serum MIC‐1 is a valuable biomarker for the diagnosis and prognosis of NSCLC.
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spelling pubmed-79571682021-03-19 Serum macrophage inhibitory cytokine‐1 as a clinical marker for non–small cell lung cancer Xu, Chunhua Li, Li Wang, Wei Zhang, Qian Zhang, Xiuwei Yang, Rusong J Cell Mol Med Short Communication The aim of this study was to investigate the value of serum macrophage inhibitory factor‐1 (MIC‐1) level in patients with non–small cell lung cancer (NSCLC). Serum samples from 296 patients with NSCLC and 240 healthy controls were collected. The levels of serum MIC‐1 were determined by ELISA. The serum MIC‐1 levels in NSCLC patients were higher than that of the controls (P <.001). Univariate and multivariate Cox regression analysis showed that serum MIC‐1 was an independent prognostic indicator of OS and PFS. Serum MIC‐1 is a valuable biomarker for the diagnosis and prognosis of NSCLC. John Wiley and Sons Inc. 2021-02-18 2021-03 /pmc/articles/PMC7957168/ /pubmed/33605059 http://dx.doi.org/10.1111/jcmm.16360 Text en © 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Xu, Chunhua
Li, Li
Wang, Wei
Zhang, Qian
Zhang, Xiuwei
Yang, Rusong
Serum macrophage inhibitory cytokine‐1 as a clinical marker for non–small cell lung cancer
title Serum macrophage inhibitory cytokine‐1 as a clinical marker for non–small cell lung cancer
title_full Serum macrophage inhibitory cytokine‐1 as a clinical marker for non–small cell lung cancer
title_fullStr Serum macrophage inhibitory cytokine‐1 as a clinical marker for non–small cell lung cancer
title_full_unstemmed Serum macrophage inhibitory cytokine‐1 as a clinical marker for non–small cell lung cancer
title_short Serum macrophage inhibitory cytokine‐1 as a clinical marker for non–small cell lung cancer
title_sort serum macrophage inhibitory cytokine‐1 as a clinical marker for non–small cell lung cancer
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957168/
https://www.ncbi.nlm.nih.gov/pubmed/33605059
http://dx.doi.org/10.1111/jcmm.16360
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