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Body composition and risk of gastric cancer: A population‐based prospective cohort study
The recognition of adiposity as a risk factor for gastric cancer is mainly based on traditional anthropometric indices, such as body mass index, which are unable to discriminate between lean and fat mass. We undertook this study to examine body composition and subsequent risk of gastric cancer. This...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957174/ https://www.ncbi.nlm.nih.gov/pubmed/33624430 http://dx.doi.org/10.1002/cam4.3808 |
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author | Liu, An‐Ran He, Qiang‐Sheng Wu, Wen‐Hui Du, Jian‐Liang Kuo, Zi‐Chong Xia, Bin Tang, Yan Yun, Peng Cheung, Eddie C. Tang, You‐Zhen He, Yu‐Long Zhang, Chang‐Hua Yuan, Jin‐Qiu Sun, Gang |
author_facet | Liu, An‐Ran He, Qiang‐Sheng Wu, Wen‐Hui Du, Jian‐Liang Kuo, Zi‐Chong Xia, Bin Tang, Yan Yun, Peng Cheung, Eddie C. Tang, You‐Zhen He, Yu‐Long Zhang, Chang‐Hua Yuan, Jin‐Qiu Sun, Gang |
author_sort | Liu, An‐Ran |
collection | PubMed |
description | The recognition of adiposity as a risk factor for gastric cancer is mainly based on traditional anthropometric indices, such as body mass index, which are unable to discriminate between lean and fat mass. We undertook this study to examine body composition and subsequent risk of gastric cancer. This is a prospective analysis of participants free of cancer from the UK Biobank. We measured baseline body composition with electrical bioimpedance analysis and confirmed cancer diagnosis through linkage to cancer and death registries. We evaluated hazard ratios (HRs) and confidence interval (CIs) with COX models adjusting for potential confounders. We documented 326 cases of cancer from 474,929 participants over a median follow‐up of 6.6 years. Both male (HR 1.70, 95% CI 1.01 to 2.89) and female participants (HR 2.47, 95% CI 1.15 to 5.32) in the highest quartile of whole body fat‐free mass were associated with increased risk of gastric cancer as compared with those in the lowest quartile.Whole body fat mass was associated with a decreased risk of gastric cancer (HR per 5‐unit increase 0.86, 95% CI 0.74 to 0.99) in females, but not in males. We concluded that fat‐free mass and fat mass may have different effects on gastric cancer risk. This study provided evidence for individualized weight management for the prevention of gastric cancer. |
format | Online Article Text |
id | pubmed-7957174 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79571742021-03-19 Body composition and risk of gastric cancer: A population‐based prospective cohort study Liu, An‐Ran He, Qiang‐Sheng Wu, Wen‐Hui Du, Jian‐Liang Kuo, Zi‐Chong Xia, Bin Tang, Yan Yun, Peng Cheung, Eddie C. Tang, You‐Zhen He, Yu‐Long Zhang, Chang‐Hua Yuan, Jin‐Qiu Sun, Gang Cancer Med Cancer Prevention The recognition of adiposity as a risk factor for gastric cancer is mainly based on traditional anthropometric indices, such as body mass index, which are unable to discriminate between lean and fat mass. We undertook this study to examine body composition and subsequent risk of gastric cancer. This is a prospective analysis of participants free of cancer from the UK Biobank. We measured baseline body composition with electrical bioimpedance analysis and confirmed cancer diagnosis through linkage to cancer and death registries. We evaluated hazard ratios (HRs) and confidence interval (CIs) with COX models adjusting for potential confounders. We documented 326 cases of cancer from 474,929 participants over a median follow‐up of 6.6 years. Both male (HR 1.70, 95% CI 1.01 to 2.89) and female participants (HR 2.47, 95% CI 1.15 to 5.32) in the highest quartile of whole body fat‐free mass were associated with increased risk of gastric cancer as compared with those in the lowest quartile.Whole body fat mass was associated with a decreased risk of gastric cancer (HR per 5‐unit increase 0.86, 95% CI 0.74 to 0.99) in females, but not in males. We concluded that fat‐free mass and fat mass may have different effects on gastric cancer risk. This study provided evidence for individualized weight management for the prevention of gastric cancer. John Wiley and Sons Inc. 2021-02-23 /pmc/articles/PMC7957174/ /pubmed/33624430 http://dx.doi.org/10.1002/cam4.3808 Text en © 2021 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Cancer Prevention Liu, An‐Ran He, Qiang‐Sheng Wu, Wen‐Hui Du, Jian‐Liang Kuo, Zi‐Chong Xia, Bin Tang, Yan Yun, Peng Cheung, Eddie C. Tang, You‐Zhen He, Yu‐Long Zhang, Chang‐Hua Yuan, Jin‐Qiu Sun, Gang Body composition and risk of gastric cancer: A population‐based prospective cohort study |
title | Body composition and risk of gastric cancer: A population‐based prospective cohort study |
title_full | Body composition and risk of gastric cancer: A population‐based prospective cohort study |
title_fullStr | Body composition and risk of gastric cancer: A population‐based prospective cohort study |
title_full_unstemmed | Body composition and risk of gastric cancer: A population‐based prospective cohort study |
title_short | Body composition and risk of gastric cancer: A population‐based prospective cohort study |
title_sort | body composition and risk of gastric cancer: a population‐based prospective cohort study |
topic | Cancer Prevention |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957174/ https://www.ncbi.nlm.nih.gov/pubmed/33624430 http://dx.doi.org/10.1002/cam4.3808 |
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