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Body composition and risk of gastric cancer: A population‐based prospective cohort study

The recognition of adiposity as a risk factor for gastric cancer is mainly based on traditional anthropometric indices, such as body mass index, which are unable to discriminate between lean and fat mass. We undertook this study to examine body composition and subsequent risk of gastric cancer. This...

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Autores principales: Liu, An‐Ran, He, Qiang‐Sheng, Wu, Wen‐Hui, Du, Jian‐Liang, Kuo, Zi‐Chong, Xia, Bin, Tang, Yan, Yun, Peng, Cheung, Eddie C., Tang, You‐Zhen, He, Yu‐Long, Zhang, Chang‐Hua, Yuan, Jin‐Qiu, Sun, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957174/
https://www.ncbi.nlm.nih.gov/pubmed/33624430
http://dx.doi.org/10.1002/cam4.3808
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author Liu, An‐Ran
He, Qiang‐Sheng
Wu, Wen‐Hui
Du, Jian‐Liang
Kuo, Zi‐Chong
Xia, Bin
Tang, Yan
Yun, Peng
Cheung, Eddie C.
Tang, You‐Zhen
He, Yu‐Long
Zhang, Chang‐Hua
Yuan, Jin‐Qiu
Sun, Gang
author_facet Liu, An‐Ran
He, Qiang‐Sheng
Wu, Wen‐Hui
Du, Jian‐Liang
Kuo, Zi‐Chong
Xia, Bin
Tang, Yan
Yun, Peng
Cheung, Eddie C.
Tang, You‐Zhen
He, Yu‐Long
Zhang, Chang‐Hua
Yuan, Jin‐Qiu
Sun, Gang
author_sort Liu, An‐Ran
collection PubMed
description The recognition of adiposity as a risk factor for gastric cancer is mainly based on traditional anthropometric indices, such as body mass index, which are unable to discriminate between lean and fat mass. We undertook this study to examine body composition and subsequent risk of gastric cancer. This is a prospective analysis of participants free of cancer from the UK Biobank. We measured baseline body composition with electrical bioimpedance analysis and confirmed cancer diagnosis through linkage to cancer and death registries. We evaluated hazard ratios (HRs) and confidence interval (CIs) with COX models adjusting for potential confounders. We documented 326 cases of cancer from 474,929 participants over a median follow‐up of 6.6 years. Both male (HR 1.70, 95% CI 1.01 to 2.89) and female participants (HR 2.47, 95% CI 1.15 to 5.32) in the highest quartile of whole body fat‐free mass were associated with increased risk of gastric cancer as compared with those in the lowest quartile.Whole body fat mass was associated with a decreased risk of gastric cancer (HR per 5‐unit increase 0.86, 95% CI 0.74 to 0.99) in females, but not in males. We concluded that fat‐free mass and fat mass may have different effects on gastric cancer risk. This study provided evidence for individualized weight management for the prevention of gastric cancer.
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spelling pubmed-79571742021-03-19 Body composition and risk of gastric cancer: A population‐based prospective cohort study Liu, An‐Ran He, Qiang‐Sheng Wu, Wen‐Hui Du, Jian‐Liang Kuo, Zi‐Chong Xia, Bin Tang, Yan Yun, Peng Cheung, Eddie C. Tang, You‐Zhen He, Yu‐Long Zhang, Chang‐Hua Yuan, Jin‐Qiu Sun, Gang Cancer Med Cancer Prevention The recognition of adiposity as a risk factor for gastric cancer is mainly based on traditional anthropometric indices, such as body mass index, which are unable to discriminate between lean and fat mass. We undertook this study to examine body composition and subsequent risk of gastric cancer. This is a prospective analysis of participants free of cancer from the UK Biobank. We measured baseline body composition with electrical bioimpedance analysis and confirmed cancer diagnosis through linkage to cancer and death registries. We evaluated hazard ratios (HRs) and confidence interval (CIs) with COX models adjusting for potential confounders. We documented 326 cases of cancer from 474,929 participants over a median follow‐up of 6.6 years. Both male (HR 1.70, 95% CI 1.01 to 2.89) and female participants (HR 2.47, 95% CI 1.15 to 5.32) in the highest quartile of whole body fat‐free mass were associated with increased risk of gastric cancer as compared with those in the lowest quartile.Whole body fat mass was associated with a decreased risk of gastric cancer (HR per 5‐unit increase 0.86, 95% CI 0.74 to 0.99) in females, but not in males. We concluded that fat‐free mass and fat mass may have different effects on gastric cancer risk. This study provided evidence for individualized weight management for the prevention of gastric cancer. John Wiley and Sons Inc. 2021-02-23 /pmc/articles/PMC7957174/ /pubmed/33624430 http://dx.doi.org/10.1002/cam4.3808 Text en © 2021 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cancer Prevention
Liu, An‐Ran
He, Qiang‐Sheng
Wu, Wen‐Hui
Du, Jian‐Liang
Kuo, Zi‐Chong
Xia, Bin
Tang, Yan
Yun, Peng
Cheung, Eddie C.
Tang, You‐Zhen
He, Yu‐Long
Zhang, Chang‐Hua
Yuan, Jin‐Qiu
Sun, Gang
Body composition and risk of gastric cancer: A population‐based prospective cohort study
title Body composition and risk of gastric cancer: A population‐based prospective cohort study
title_full Body composition and risk of gastric cancer: A population‐based prospective cohort study
title_fullStr Body composition and risk of gastric cancer: A population‐based prospective cohort study
title_full_unstemmed Body composition and risk of gastric cancer: A population‐based prospective cohort study
title_short Body composition and risk of gastric cancer: A population‐based prospective cohort study
title_sort body composition and risk of gastric cancer: a population‐based prospective cohort study
topic Cancer Prevention
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957174/
https://www.ncbi.nlm.nih.gov/pubmed/33624430
http://dx.doi.org/10.1002/cam4.3808
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