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AMPK inhibits Smad3‐mediated autoinduction of TGF‐β1 in gastric cancer cells

We have previously shown that adenine monophosphate‐activated protein kinase (AMPK) regulates transforming growth factor β (TGF‐β)‐triggered Smad3 phosphorylation. Here we report that AMPK inhibits TGF‐β1 production. First, metformin reduced mRNA levels of TGF‐β1 in gastric cancer cells, in parallel...

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Detalles Bibliográficos
Autores principales:	Zou, Junrong, Li, Cong, Jiang, Shanshan, Luo, Lingyu, Yan, Xiaohua, Huang, Deqiang, Luo, Zhijun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957200/ https://www.ncbi.nlm.nih.gov/pubmed/33538080 http://dx.doi.org/10.1111/jcmm.16308

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