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Prognostic values and immune suppression of the S100A family in pancreatic cancer
S100 calcium‐binding protein A (S100A) family members regulate multiple biological functions related to pancreatic cancer (PC) progression and metastasis. However, the prognostic and oncologic values of S100A family have not been systematically investigated in PC. In the present study, the mRNA expr...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957204/ https://www.ncbi.nlm.nih.gov/pubmed/33580614 http://dx.doi.org/10.1111/jcmm.16343 |
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author | Zhuang, Hongkai Chen, Xinming Dong, Fengying Zhang, Zedan Zhou, Zixuan Ma, Zuyi Huang, Shanzhou Chen, Bo Zhang, Chuanzhao Hou, Baohua |
author_facet | Zhuang, Hongkai Chen, Xinming Dong, Fengying Zhang, Zedan Zhou, Zixuan Ma, Zuyi Huang, Shanzhou Chen, Bo Zhang, Chuanzhao Hou, Baohua |
author_sort | Zhuang, Hongkai |
collection | PubMed |
description | S100 calcium‐binding protein A (S100A) family members regulate multiple biological functions related to pancreatic cancer (PC) progression and metastasis. However, the prognostic and oncologic values of S100A family have not been systematically investigated in PC. In the present study, the mRNA expression and potential functions of S100A family were investigated by bioinformatic analysis. Our results demonstrated that overexpression of S100A2, S100A6, S100A10, S100A11, S100A14 and S100A16 was significantly associated with higher T stage, advanced histologic grade and worse prognosis in PC. Besides, one CpG of S100A2, three CpG of S100A6, four CpG of S100A10, four CpG of S100A11, two CpG of S100A14 and five CpG of S100A16 were negatively associated with corresponding S100A family members expression and positively associated with overall survival (OS). The signature based on four CpGs showed good prediction ability of OS. Besides, S100A2 overexpression took part in the regulation of mitotic cell cycle, ECM‐receptor interaction and HIF‐1α transcription factor network. Overexpression of S100A6, S100A10, S100A11, S100A14 and S100A16 may impair the infiltration and cytolytic activity of CD8(+) T cells through focal adhesion‐Ras‐stimulating signalling pathway in PC. Overall, this study explores the multiple prognostic values and oncologic functions of the S100A family in PC. |
format | Online Article Text |
id | pubmed-7957204 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79572042021-03-19 Prognostic values and immune suppression of the S100A family in pancreatic cancer Zhuang, Hongkai Chen, Xinming Dong, Fengying Zhang, Zedan Zhou, Zixuan Ma, Zuyi Huang, Shanzhou Chen, Bo Zhang, Chuanzhao Hou, Baohua J Cell Mol Med Original Articles S100 calcium‐binding protein A (S100A) family members regulate multiple biological functions related to pancreatic cancer (PC) progression and metastasis. However, the prognostic and oncologic values of S100A family have not been systematically investigated in PC. In the present study, the mRNA expression and potential functions of S100A family were investigated by bioinformatic analysis. Our results demonstrated that overexpression of S100A2, S100A6, S100A10, S100A11, S100A14 and S100A16 was significantly associated with higher T stage, advanced histologic grade and worse prognosis in PC. Besides, one CpG of S100A2, three CpG of S100A6, four CpG of S100A10, four CpG of S100A11, two CpG of S100A14 and five CpG of S100A16 were negatively associated with corresponding S100A family members expression and positively associated with overall survival (OS). The signature based on four CpGs showed good prediction ability of OS. Besides, S100A2 overexpression took part in the regulation of mitotic cell cycle, ECM‐receptor interaction and HIF‐1α transcription factor network. Overexpression of S100A6, S100A10, S100A11, S100A14 and S100A16 may impair the infiltration and cytolytic activity of CD8(+) T cells through focal adhesion‐Ras‐stimulating signalling pathway in PC. Overall, this study explores the multiple prognostic values and oncologic functions of the S100A family in PC. John Wiley and Sons Inc. 2021-02-12 2021-03 /pmc/articles/PMC7957204/ /pubmed/33580614 http://dx.doi.org/10.1111/jcmm.16343 Text en © 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Zhuang, Hongkai Chen, Xinming Dong, Fengying Zhang, Zedan Zhou, Zixuan Ma, Zuyi Huang, Shanzhou Chen, Bo Zhang, Chuanzhao Hou, Baohua Prognostic values and immune suppression of the S100A family in pancreatic cancer |
title | Prognostic values and immune suppression of the S100A family in pancreatic cancer |
title_full | Prognostic values and immune suppression of the S100A family in pancreatic cancer |
title_fullStr | Prognostic values and immune suppression of the S100A family in pancreatic cancer |
title_full_unstemmed | Prognostic values and immune suppression of the S100A family in pancreatic cancer |
title_short | Prognostic values and immune suppression of the S100A family in pancreatic cancer |
title_sort | prognostic values and immune suppression of the s100a family in pancreatic cancer |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957204/ https://www.ncbi.nlm.nih.gov/pubmed/33580614 http://dx.doi.org/10.1111/jcmm.16343 |
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