Germ cell differentiation requires Tdrd7-dependent chromatin and transcriptome reprogramming marked by germ plasm relocalization

In many animal models, primordial germ cell (PGC) development depends on maternally deposited germ plasm, which prevents somatic cell fate. Here, we show that PGCs respond to regulatory information from the germ plasm in two distinct phases using two distinct mechanisms in zebrafish. We demonstrate...

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Detalles Bibliográficos
Autores principales: D’Orazio, Fabio M., Balwierz, Piotr J., González, Ada Jimenez, Guo, Yixuan, Hernández-Rodríguez, Benjamín, Wheatley, Lucy, Jasiulewicz, Aleksandra, Hadzhiev, Yavor, Vaquerizas, Juan M., Cairns, Bradley, Lenhard, Boris, Müller, Ferenc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957325/
https://www.ncbi.nlm.nih.gov/pubmed/33651978
http://dx.doi.org/10.1016/j.devcel.2021.02.007

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