The Cross-Talk between Mesenchymal Stem Cells and Immune Cells in Tissue Repair and Regeneration

Mesenchymal stem cells (MSCs) are self-renewable, rapidly proliferating, multipotent stem cells which reside in almost all post-natal tissues. MSCs possess potent immunoregulatory properties and, in juxtacrine and paracrine manner, modulate phenotype and function of all immune cells that participate...

Descripción completa

Detalles Bibliográficos
Autores principales: Harrell, Carl Randall, Djonov, Valentin, Volarevic, Vladislav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957490/
https://www.ncbi.nlm.nih.gov/pubmed/33804369
http://dx.doi.org/10.3390/ijms22052472
_version_ 1783664660459814912
author Harrell, Carl Randall
Djonov, Valentin
Volarevic, Vladislav
author_facet Harrell, Carl Randall
Djonov, Valentin
Volarevic, Vladislav
author_sort Harrell, Carl Randall
collection PubMed
description Mesenchymal stem cells (MSCs) are self-renewable, rapidly proliferating, multipotent stem cells which reside in almost all post-natal tissues. MSCs possess potent immunoregulatory properties and, in juxtacrine and paracrine manner, modulate phenotype and function of all immune cells that participate in tissue repair and regeneration. Additionally, MSCs produce various pro-angiogenic factors and promote neo-vascularization in healing tissues, contributing to their enhanced repair and regeneration. In this review article, we summarized current knowledge about molecular mechanisms that regulate the crosstalk between MSCs and immune cells in tissue repair and regeneration.
format Online
Article
Text
id pubmed-7957490
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-79574902021-03-16 The Cross-Talk between Mesenchymal Stem Cells and Immune Cells in Tissue Repair and Regeneration Harrell, Carl Randall Djonov, Valentin Volarevic, Vladislav Int J Mol Sci Review Mesenchymal stem cells (MSCs) are self-renewable, rapidly proliferating, multipotent stem cells which reside in almost all post-natal tissues. MSCs possess potent immunoregulatory properties and, in juxtacrine and paracrine manner, modulate phenotype and function of all immune cells that participate in tissue repair and regeneration. Additionally, MSCs produce various pro-angiogenic factors and promote neo-vascularization in healing tissues, contributing to their enhanced repair and regeneration. In this review article, we summarized current knowledge about molecular mechanisms that regulate the crosstalk between MSCs and immune cells in tissue repair and regeneration. MDPI 2021-03-01 /pmc/articles/PMC7957490/ /pubmed/33804369 http://dx.doi.org/10.3390/ijms22052472 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Harrell, Carl Randall
Djonov, Valentin
Volarevic, Vladislav
The Cross-Talk between Mesenchymal Stem Cells and Immune Cells in Tissue Repair and Regeneration
title The Cross-Talk between Mesenchymal Stem Cells and Immune Cells in Tissue Repair and Regeneration
title_full The Cross-Talk between Mesenchymal Stem Cells and Immune Cells in Tissue Repair and Regeneration
title_fullStr The Cross-Talk between Mesenchymal Stem Cells and Immune Cells in Tissue Repair and Regeneration
title_full_unstemmed The Cross-Talk between Mesenchymal Stem Cells and Immune Cells in Tissue Repair and Regeneration
title_short The Cross-Talk between Mesenchymal Stem Cells and Immune Cells in Tissue Repair and Regeneration
title_sort cross-talk between mesenchymal stem cells and immune cells in tissue repair and regeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957490/
https://www.ncbi.nlm.nih.gov/pubmed/33804369
http://dx.doi.org/10.3390/ijms22052472
work_keys_str_mv AT harrellcarlrandall thecrosstalkbetweenmesenchymalstemcellsandimmunecellsintissuerepairandregeneration
AT djonovvalentin thecrosstalkbetweenmesenchymalstemcellsandimmunecellsintissuerepairandregeneration
AT volarevicvladislav thecrosstalkbetweenmesenchymalstemcellsandimmunecellsintissuerepairandregeneration
AT harrellcarlrandall crosstalkbetweenmesenchymalstemcellsandimmunecellsintissuerepairandregeneration
AT djonovvalentin crosstalkbetweenmesenchymalstemcellsandimmunecellsintissuerepairandregeneration
AT volarevicvladislav crosstalkbetweenmesenchymalstemcellsandimmunecellsintissuerepairandregeneration

Ejemplares similares