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A Sensitive and Fast Fiber Bragg Grating-Based Investigation of the Biomechanical Dynamics of In Vitro Spinal Cord Injuries

To better understand the real-time biomechanics of soft tissues under sudden mechanical loads such as traumatic spinal cord injury (SCI), it is important to improve in vitro models. During a traumatic SCI, the spinal cord suffers high-velocity compression. The evaluation of spinal canal occlusion wi...

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Autores principales: Mishra, Satyendra Kumar, Mac-Thiong, Jean-Marc, Wagnac, Éric, Petit, Yvan, Ung, Bora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957506/
https://www.ncbi.nlm.nih.gov/pubmed/33804327
http://dx.doi.org/10.3390/s21051671
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author Mishra, Satyendra Kumar
Mac-Thiong, Jean-Marc
Wagnac, Éric
Petit, Yvan
Ung, Bora
author_facet Mishra, Satyendra Kumar
Mac-Thiong, Jean-Marc
Wagnac, Éric
Petit, Yvan
Ung, Bora
author_sort Mishra, Satyendra Kumar
collection PubMed
description To better understand the real-time biomechanics of soft tissues under sudden mechanical loads such as traumatic spinal cord injury (SCI), it is important to improve in vitro models. During a traumatic SCI, the spinal cord suffers high-velocity compression. The evaluation of spinal canal occlusion with a sensor is required in order to investigate the degree of spinal compression and the fast biomechanical processes involved. Unfortunately, available techniques suffer with drawbacks such as the inability to measure transverse compression and impractically large response times. In this work, an optical pressure sensing scheme based on a fiber Bragg grating and a narrow-band filter was designed to detect and demonstrate the transverse compression inside a spinal cord surrogate in real-time. The response time of the proposed scheme was 20 microseconds; a five orders of magnitude enhancement over comparable schemes that depend on costly and slower optical spectral analyzers. We further showed that this improvement in speed comes with a negligible loss in sensitivity. This study is another step towards better understanding the complex biomechanics involved during a traumatic SCI, using a method capable of probing the related internal strains with high-spatiotemporal resolution.
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spelling pubmed-79575062021-03-16 A Sensitive and Fast Fiber Bragg Grating-Based Investigation of the Biomechanical Dynamics of In Vitro Spinal Cord Injuries Mishra, Satyendra Kumar Mac-Thiong, Jean-Marc Wagnac, Éric Petit, Yvan Ung, Bora Sensors (Basel) Communication To better understand the real-time biomechanics of soft tissues under sudden mechanical loads such as traumatic spinal cord injury (SCI), it is important to improve in vitro models. During a traumatic SCI, the spinal cord suffers high-velocity compression. The evaluation of spinal canal occlusion with a sensor is required in order to investigate the degree of spinal compression and the fast biomechanical processes involved. Unfortunately, available techniques suffer with drawbacks such as the inability to measure transverse compression and impractically large response times. In this work, an optical pressure sensing scheme based on a fiber Bragg grating and a narrow-band filter was designed to detect and demonstrate the transverse compression inside a spinal cord surrogate in real-time. The response time of the proposed scheme was 20 microseconds; a five orders of magnitude enhancement over comparable schemes that depend on costly and slower optical spectral analyzers. We further showed that this improvement in speed comes with a negligible loss in sensitivity. This study is another step towards better understanding the complex biomechanics involved during a traumatic SCI, using a method capable of probing the related internal strains with high-spatiotemporal resolution. MDPI 2021-03-01 /pmc/articles/PMC7957506/ /pubmed/33804327 http://dx.doi.org/10.3390/s21051671 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Mishra, Satyendra Kumar
Mac-Thiong, Jean-Marc
Wagnac, Éric
Petit, Yvan
Ung, Bora
A Sensitive and Fast Fiber Bragg Grating-Based Investigation of the Biomechanical Dynamics of In Vitro Spinal Cord Injuries
title A Sensitive and Fast Fiber Bragg Grating-Based Investigation of the Biomechanical Dynamics of In Vitro Spinal Cord Injuries
title_full A Sensitive and Fast Fiber Bragg Grating-Based Investigation of the Biomechanical Dynamics of In Vitro Spinal Cord Injuries
title_fullStr A Sensitive and Fast Fiber Bragg Grating-Based Investigation of the Biomechanical Dynamics of In Vitro Spinal Cord Injuries
title_full_unstemmed A Sensitive and Fast Fiber Bragg Grating-Based Investigation of the Biomechanical Dynamics of In Vitro Spinal Cord Injuries
title_short A Sensitive and Fast Fiber Bragg Grating-Based Investigation of the Biomechanical Dynamics of In Vitro Spinal Cord Injuries
title_sort sensitive and fast fiber bragg grating-based investigation of the biomechanical dynamics of in vitro spinal cord injuries
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957506/
https://www.ncbi.nlm.nih.gov/pubmed/33804327
http://dx.doi.org/10.3390/s21051671
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