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Effects of Lyophilization on the Release Profiles of 3D Printed Delivery Systems Fabricated with Carboxymethyl Cellulose Hydrogel
Recently, increasing numbers of researchers are becoming interested in 3D bioprinting because it provides customizability and structural complexity, which is difficult for traditional subtractive manufacturing to achieve. One of the most critical factors in bioprinting is the material. Depending on...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957655/ https://www.ncbi.nlm.nih.gov/pubmed/33670898 http://dx.doi.org/10.3390/polym13050749 |
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author | Jiang, Xuepeng Huang, Yanhua Cheng, Yiliang Zhang, Zhan Shi, Xiaolei Qin, Hantang |
author_facet | Jiang, Xuepeng Huang, Yanhua Cheng, Yiliang Zhang, Zhan Shi, Xiaolei Qin, Hantang |
author_sort | Jiang, Xuepeng |
collection | PubMed |
description | Recently, increasing numbers of researchers are becoming interested in 3D bioprinting because it provides customizability and structural complexity, which is difficult for traditional subtractive manufacturing to achieve. One of the most critical factors in bioprinting is the material. Depending on the bio-applications, materials should be bio-inert or bio-active, non-toxic, and along with those characteristics, mechanical properties should also meet the applicational or manufacturing requirement. As previously validated for bioprinting, carboxymethyl cellulose (CMC) hydrogel is focused on the printability and release control test in this study. With a differentiated weight percentage of CMC hydrogels were used to 3D print capsules filled with food degradable colorant at designated voids to mimic capsules manufactured for oral delivery. Standard USP (United States Pharmacopeia) dissolution apparatus II (Paddle) evaluations were performed both on lyophilized and non-lyophilized printed capsules. The first-order model was selected due to high linear fitting regression. Upon 24 h dissolution, non-lyophilized capsules showed a different release efficiency when the CMC percentage varied, while lyophilized capsules showed no significant difference. This study signifies the possibility of customizing oral drug delivery by printing capsules with CMC hydrogel. The improved delivery efficiency demonstrated by capsules with post-process lyophilizing proposed potential optimization options for pharmaceutical manufacturing industries. |
format | Online Article Text |
id | pubmed-7957655 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79576552021-03-16 Effects of Lyophilization on the Release Profiles of 3D Printed Delivery Systems Fabricated with Carboxymethyl Cellulose Hydrogel Jiang, Xuepeng Huang, Yanhua Cheng, Yiliang Zhang, Zhan Shi, Xiaolei Qin, Hantang Polymers (Basel) Article Recently, increasing numbers of researchers are becoming interested in 3D bioprinting because it provides customizability and structural complexity, which is difficult for traditional subtractive manufacturing to achieve. One of the most critical factors in bioprinting is the material. Depending on the bio-applications, materials should be bio-inert or bio-active, non-toxic, and along with those characteristics, mechanical properties should also meet the applicational or manufacturing requirement. As previously validated for bioprinting, carboxymethyl cellulose (CMC) hydrogel is focused on the printability and release control test in this study. With a differentiated weight percentage of CMC hydrogels were used to 3D print capsules filled with food degradable colorant at designated voids to mimic capsules manufactured for oral delivery. Standard USP (United States Pharmacopeia) dissolution apparatus II (Paddle) evaluations were performed both on lyophilized and non-lyophilized printed capsules. The first-order model was selected due to high linear fitting regression. Upon 24 h dissolution, non-lyophilized capsules showed a different release efficiency when the CMC percentage varied, while lyophilized capsules showed no significant difference. This study signifies the possibility of customizing oral drug delivery by printing capsules with CMC hydrogel. The improved delivery efficiency demonstrated by capsules with post-process lyophilizing proposed potential optimization options for pharmaceutical manufacturing industries. MDPI 2021-02-28 /pmc/articles/PMC7957655/ /pubmed/33670898 http://dx.doi.org/10.3390/polym13050749 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Jiang, Xuepeng Huang, Yanhua Cheng, Yiliang Zhang, Zhan Shi, Xiaolei Qin, Hantang Effects of Lyophilization on the Release Profiles of 3D Printed Delivery Systems Fabricated with Carboxymethyl Cellulose Hydrogel |
title | Effects of Lyophilization on the Release Profiles of 3D Printed Delivery Systems Fabricated with Carboxymethyl Cellulose Hydrogel |
title_full | Effects of Lyophilization on the Release Profiles of 3D Printed Delivery Systems Fabricated with Carboxymethyl Cellulose Hydrogel |
title_fullStr | Effects of Lyophilization on the Release Profiles of 3D Printed Delivery Systems Fabricated with Carboxymethyl Cellulose Hydrogel |
title_full_unstemmed | Effects of Lyophilization on the Release Profiles of 3D Printed Delivery Systems Fabricated with Carboxymethyl Cellulose Hydrogel |
title_short | Effects of Lyophilization on the Release Profiles of 3D Printed Delivery Systems Fabricated with Carboxymethyl Cellulose Hydrogel |
title_sort | effects of lyophilization on the release profiles of 3d printed delivery systems fabricated with carboxymethyl cellulose hydrogel |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957655/ https://www.ncbi.nlm.nih.gov/pubmed/33670898 http://dx.doi.org/10.3390/polym13050749 |
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