The Synergism between DHODH Inhibitors and Dipyridamole Leads to Metabolic Lethality in Acute Myeloid Leukemia

SIMPLE SUMMARY: In this study, we investigated and boosted the pro-apoptotic and pro-differentiating activity of MEDS433 in acute myeloid leukemia (AML). MEDS433 is an inhibitor of Dihydroorotate Dehydrogenase, a fundamental enzyme in the de novo pyrimidine biosynthesis. We discovered that MEDS433 a...

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Detalles Bibliográficos
Autores principales: Gaidano, Valentina, Houshmand, Mohammad, Vitale, Nicoletta, Carrà, Giovanna, Morotti, Alessandro, Tenace, Valerio, Rapelli, Stefania, Sainas, Stefano, Pippione, Agnese Chiara, Giorgis, Marta, Boschi, Donatella, Lolli, Marco Lucio, Cilloni, Daniela, Cignetti, Alessandro, Saglio, Giuseppe, Circosta, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957697/
https://www.ncbi.nlm.nih.gov/pubmed/33670894
http://dx.doi.org/10.3390/cancers13051003

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