Cargando…
Osthol Ameliorates Kidney Damage and Metabolic Syndrome Induced by a High-Fat/High-Sugar Diet
Excessive intake of fructose results in metabolic syndrome (MS) and kidney damage, partly mediated by its metabolism by fructokinase-C or ketohexokinase-C (KHK-C). Osthol has antioxidant properties, is capable of regulating adipogenesis, and inhibits KHK-C activity. Here, we examined the potential p...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957708/ https://www.ncbi.nlm.nih.gov/pubmed/33670975 http://dx.doi.org/10.3390/ijms22052431 |
_version_ | 1783664711378665472 |
---|---|
author | García-Arroyo, Fernando E. Gonzaga-Sánchez, Guillermo Tapia, Edilia Muñoz-Jiménez, Itzel Manterola-Romero, Lino Osorio-Alonso, Horacio Arellano-Buendía, Abraham S. Pedraza-Chaverri, José Roncal-Jiménez, Carlos A. Lanaspa, Miguel A. Johnson, Richard J. Sánchez-Lozada, Laura Gabriela |
author_facet | García-Arroyo, Fernando E. Gonzaga-Sánchez, Guillermo Tapia, Edilia Muñoz-Jiménez, Itzel Manterola-Romero, Lino Osorio-Alonso, Horacio Arellano-Buendía, Abraham S. Pedraza-Chaverri, José Roncal-Jiménez, Carlos A. Lanaspa, Miguel A. Johnson, Richard J. Sánchez-Lozada, Laura Gabriela |
author_sort | García-Arroyo, Fernando E. |
collection | PubMed |
description | Excessive intake of fructose results in metabolic syndrome (MS) and kidney damage, partly mediated by its metabolism by fructokinase-C or ketohexokinase-C (KHK-C). Osthol has antioxidant properties, is capable of regulating adipogenesis, and inhibits KHK-C activity. Here, we examined the potential protective role of osthol in the development of kidney disease induced by a Western (high-fat/high-sugar) diet. Control rats fed with a high-fat/high-sugar diet were compared with two groups that also received two different doses of osthol (30 mg/kg/d or 40 mg/kg/d body weight BW). A fourth group served as a normal control and received regular chow. At the end of the follow-up, kidney function, metabolic markers, oxidative stress, and lipogenic enzymes were evaluated. The Western diet induced MS (hypertension, hyperglycemia, hypertriglyceridemia, obesity, hyperuricemia), a fall in the glomerular filtration rate, renal tubular damage, and increased oxidative stress in the kidney cortex, with increased expression of lipogenic enzymes and increased kidney KHK expression. Osthol treatment prevented the development of MS and ameliorated kidney damage by inhibiting KHK activity, preventing oxidative stress via nuclear factor erythroid 2-related factor (Nrf2) activation, and reducing renal lipotoxicity. These data suggest that the nutraceutical osthol might be an ancillary therapy to slow the progression of MS and kidney damage induced by a Western diet. |
format | Online Article Text |
id | pubmed-7957708 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79577082021-03-16 Osthol Ameliorates Kidney Damage and Metabolic Syndrome Induced by a High-Fat/High-Sugar Diet García-Arroyo, Fernando E. Gonzaga-Sánchez, Guillermo Tapia, Edilia Muñoz-Jiménez, Itzel Manterola-Romero, Lino Osorio-Alonso, Horacio Arellano-Buendía, Abraham S. Pedraza-Chaverri, José Roncal-Jiménez, Carlos A. Lanaspa, Miguel A. Johnson, Richard J. Sánchez-Lozada, Laura Gabriela Int J Mol Sci Article Excessive intake of fructose results in metabolic syndrome (MS) and kidney damage, partly mediated by its metabolism by fructokinase-C or ketohexokinase-C (KHK-C). Osthol has antioxidant properties, is capable of regulating adipogenesis, and inhibits KHK-C activity. Here, we examined the potential protective role of osthol in the development of kidney disease induced by a Western (high-fat/high-sugar) diet. Control rats fed with a high-fat/high-sugar diet were compared with two groups that also received two different doses of osthol (30 mg/kg/d or 40 mg/kg/d body weight BW). A fourth group served as a normal control and received regular chow. At the end of the follow-up, kidney function, metabolic markers, oxidative stress, and lipogenic enzymes were evaluated. The Western diet induced MS (hypertension, hyperglycemia, hypertriglyceridemia, obesity, hyperuricemia), a fall in the glomerular filtration rate, renal tubular damage, and increased oxidative stress in the kidney cortex, with increased expression of lipogenic enzymes and increased kidney KHK expression. Osthol treatment prevented the development of MS and ameliorated kidney damage by inhibiting KHK activity, preventing oxidative stress via nuclear factor erythroid 2-related factor (Nrf2) activation, and reducing renal lipotoxicity. These data suggest that the nutraceutical osthol might be an ancillary therapy to slow the progression of MS and kidney damage induced by a Western diet. MDPI 2021-02-28 /pmc/articles/PMC7957708/ /pubmed/33670975 http://dx.doi.org/10.3390/ijms22052431 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article García-Arroyo, Fernando E. Gonzaga-Sánchez, Guillermo Tapia, Edilia Muñoz-Jiménez, Itzel Manterola-Romero, Lino Osorio-Alonso, Horacio Arellano-Buendía, Abraham S. Pedraza-Chaverri, José Roncal-Jiménez, Carlos A. Lanaspa, Miguel A. Johnson, Richard J. Sánchez-Lozada, Laura Gabriela Osthol Ameliorates Kidney Damage and Metabolic Syndrome Induced by a High-Fat/High-Sugar Diet |
title | Osthol Ameliorates Kidney Damage and Metabolic Syndrome Induced by a High-Fat/High-Sugar Diet |
title_full | Osthol Ameliorates Kidney Damage and Metabolic Syndrome Induced by a High-Fat/High-Sugar Diet |
title_fullStr | Osthol Ameliorates Kidney Damage and Metabolic Syndrome Induced by a High-Fat/High-Sugar Diet |
title_full_unstemmed | Osthol Ameliorates Kidney Damage and Metabolic Syndrome Induced by a High-Fat/High-Sugar Diet |
title_short | Osthol Ameliorates Kidney Damage and Metabolic Syndrome Induced by a High-Fat/High-Sugar Diet |
title_sort | osthol ameliorates kidney damage and metabolic syndrome induced by a high-fat/high-sugar diet |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957708/ https://www.ncbi.nlm.nih.gov/pubmed/33670975 http://dx.doi.org/10.3390/ijms22052431 |
work_keys_str_mv | AT garciaarroyofernandoe ostholameliorateskidneydamageandmetabolicsyndromeinducedbyahighfathighsugardiet AT gonzagasanchezguillermo ostholameliorateskidneydamageandmetabolicsyndromeinducedbyahighfathighsugardiet AT tapiaedilia ostholameliorateskidneydamageandmetabolicsyndromeinducedbyahighfathighsugardiet AT munozjimenezitzel ostholameliorateskidneydamageandmetabolicsyndromeinducedbyahighfathighsugardiet AT manterolaromerolino ostholameliorateskidneydamageandmetabolicsyndromeinducedbyahighfathighsugardiet AT osorioalonsohoracio ostholameliorateskidneydamageandmetabolicsyndromeinducedbyahighfathighsugardiet AT arellanobuendiaabrahams ostholameliorateskidneydamageandmetabolicsyndromeinducedbyahighfathighsugardiet AT pedrazachaverrijose ostholameliorateskidneydamageandmetabolicsyndromeinducedbyahighfathighsugardiet AT roncaljimenezcarlosa ostholameliorateskidneydamageandmetabolicsyndromeinducedbyahighfathighsugardiet AT lanaspamiguela ostholameliorateskidneydamageandmetabolicsyndromeinducedbyahighfathighsugardiet AT johnsonrichardj ostholameliorateskidneydamageandmetabolicsyndromeinducedbyahighfathighsugardiet AT sanchezlozadalauragabriela ostholameliorateskidneydamageandmetabolicsyndromeinducedbyahighfathighsugardiet |