Discovery of Orally Active Isofuranones as Potent, Selective Inhibitors of Hematopoetic Progenitor Kinase 1

[Image: see text] While the discovery of immune checkpoint inhibitors has led to robust, durable responses in a range of cancers, many patients do not respond to currently available therapeutics. Therefore, an urgent need exists to identify alternative mechanisms to augment the immune-mediated clear...

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Detalles Bibliográficos
Autores principales: Degnan, Andrew P., Kumi, Godwin K., Allard, Christopher W., Araujo, Erika V., Johnson, Walter L., Zimmermann, Kurt, Pearce, Bradley C., Sheriff, Steven, Futran, Alan, Li, Xin, Locke, Gregory A., You, Dan, Morrison, John, Parrish, Karen E., Stromko, Caitlyn, Murtaza, Anwar, Liu, Jinqi, Johnson, Benjamin M., Vite, Gregory D., Wittman, Mark D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957935/
https://www.ncbi.nlm.nih.gov/pubmed/33732413
http://dx.doi.org/10.1021/acsmedchemlett.0c00660

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