Cargando…

MNK as a potential pharmacological target for suppressing LPS-induced acute lung injury in mice

Acute lung injury (ALI) or its more severe form, known as acute respiratory distress syndrome (ARDS), is characterized by an initial exudative phase, expression of proinflammatory mediators, activation of inflammatory leukocytes, and impairment of the lung endothelium and epithelium. Despite numerou...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gao, Jianfeng, Teng, Li, Yang, Sijun, Huang, Shuguang, Li, Linrui, Zhou, Li, Liu, Guoquan, Tang, Hongbin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Inc. 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957947/ https://www.ncbi.nlm.nih.gov/pubmed/33675774 http://dx.doi.org/10.1016/j.bcp.2021.114499

Ejemplares similares

MNK1 and MNK2 expression in the human dorsal root and trigeminal ganglion
por: Shiers, Stephanie, et al.
Publicado: (2023)

MNK1 and MNK2 mediate adverse effects of high-fat feeding in distinct ways
por: Moore, C. E. J., et al.
Publicado: (2016)

MNK Proteins as Therapeutic Targets in Leukemia
por: Mazewski, Candice, et al.
Publicado: (2023)

ISM1 suppresses LPS-induced acute lung injury and post-injury lung fibrosis in mice
por: Nguyen, Ngan, et al.
Publicado: (2022)

HSF1 Attenuates LPS-Induced Acute Lung Injury in Mice by Suppressing Macrophage Infiltration
por: Li, Tao, et al.
Publicado: (2020)

An Aptamer against MNK1 for Non-Small Cell Lung Cancer Treatment
por: Carrión-Marchante, Rebeca, et al.
Publicado: (2023)

The tissue specific regulation of miR22 expression in the lung and brain by ribosomal protein L29
por: Ali, Mohammad Ishaque, et al.
Publicado: (2020)

Prevention of LPS-Induced Acute Lung Injury in Mice by Progranulin
por: Guo, Zhongliang, et al.
Publicado: (2012)

Increased expression of MNK1b, the spliced isoform of MNK1, predicts poor prognosis and is associated with triple-negative breast cancer
por: Pinto-Díez, Celia, et al.
Publicado: (2018)

Small Molecules Targeting the Inactive Form of the Mnk1/2 Kinases
por: Kannan, Srinivasaraghavan, et al.
Publicado: (2017)

Role of MAPK/MNK1 signaling in virus replication
por: Kumar, Ram, et al.
Publicado: (2018)

MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma
por: Ke, Xin-Yu, et al.
Publicado: (2021)

Pharmacologic Blockade of 15-PGDH Protects Against Acute Renal Injury Induced by LPS in Mice
por: Miao, Shuying, et al.
Publicado: (2020)

Inhibition of Rac1 attenuates radiation-induced lung injury while suppresses lung tumor in mice
por: An, Ni, et al.
Publicado: (2022)

A role for pre-mNK cells in tumor progression
por: Rosinsky, Carolyn, et al.
Publicado: (2016)

Probing the Anticancer Action of Novel Ferrocene Analogues of MNK Inhibitors
por: Sansook, Supojjanee, et al.
Publicado: (2018)

Oncogenic MNK signalling regulates the metastasis suppressor NDRG1
por: Tian, Shuye, et al.
Publicado: (2017)

Inhibition of Mnk enhances apoptotic activity of cytarabine in acute myeloid leukemia cells
por: Li, Peng, et al.
Publicado: (2016)

Protective effect of TM6 on LPS-induced acute lung injury in mice
por: Hu, Xiaoyu, et al.
Publicado: (2017)

Bufexamac ameliorates LPS-induced acute lung injury in mice by targeting LTA4H
por: Xiao, Qiang, et al.
Publicado: (2016)

MicroRNA-93 contributes to the suppression of lung inflammatory responses in LPS-induced acute lung injury in mice via the TLR4/MyD88/NF-κB signaling pathway
por: Gao, Hu, et al.
Publicado: (2020)

Lung-protective effect of Punicalagin on LPS-induced acute lung injury in mice
por: Zeng, Yibin, et al.
Publicado: (2022)

Revisiting the Prominent Anti-Tumoral Potential of Pre-mNK Cells
por: Guimont-Desrochers, Fanny, et al.
Publicado: (2013)

Controlling TIME: How MNK Kinases Function to Shape Tumor Immunity
por: Pham, Thao N.D., et al.
Publicado: (2020)

Overcoming Paradoxical Kinase Priming by a Novel MNK1 Inhibitor
por: Bou-Petit, Elisabeth, et al.
Publicado: (2022)

Juglanin suppresses fibrosis and inflammation response caused by LPS in acute lung injury
por: Dong, Ze-Wu, et al.
Publicado: (2018)

FGF1 alleviates LPS-induced acute lung injury via suppression of inflammation and oxidative stress
por: Dhlamini, Qhaweni, et al.
Publicado: (2022)

Integrated metabolomics, network pharmacology and biological verification to reveal the mechanisms of Nauclea officinalis treatment of LPS-induced acute lung injury
por: Xu, Han, et al.
Publicado: (2022)

Protective effect of oxytocin on LPS-induced acute lung injury in mice
por: An, Xiaona, et al.
Publicado: (2019)

The MNK1/2-eIF4E Axis as a Potential Therapeutic Target in Melanoma
por: Prabhu, Sathyen A., et al.
Publicado: (2020)

Metabolomics coupled with network pharmacology study on the protective effect of Keguan-1 granules in LPS-induced acute lung injury
por: Chen, Shuaishuai, et al.
Publicado: (2022)

MNK2 deficiency potentiates β-cell regeneration via translational regulation
por: Karampelias, Christos, et al.
Publicado: (2022)

Suppression of lung inflammation in an LPS-induced acute lung injury model by the fruit hull of Gleditsia sinensis
por: Kim, Kyun Ha, et al.
Publicado: (2014)

MNK inhibitor eFT508 (Tomivosertib) suppresses ectopic activity in human dorsal root ganglion neurons from dermatomes with radicular neuropathic pain
por: Li, Yan, et al.
Publicado: (2023)

Disabling MNK protein kinases promotes oxidative metabolism and protects against diet-induced obesity
por: Sandeman, Lauren Y., et al.
Publicado: (2020)

Protective effects of aerobic exercise on acute lung injury induced by LPS in mice
por: Reis Gonçalves, Cintia Tokio, et al.
Publicado: (2012)

LINC00924-induced fatty acid metabolic reprogramming facilitates gastric cancer peritoneal metastasis via hnRNPC-regulated alternative splicing of Mnk2
por: He, Qiuming, et al.
Publicado: (2022)

Poncirin suppresses lipopolysaccharide (LPS)-induced microglial inflammation and ameliorates brain ischemic injury in experimental stroke in mice
por: Yang, Li-Xuan, et al.
Publicado: (2020)

Phosphorylated Mnk1 and eIF4E Are Associated with Lymph Node Metastasis and Poor Prognosis of Nasopharyngeal Carcinoma
por: Zheng, Jun, et al.
Publicado: (2014)

Design, Synthesis and Evaluation of Novel Phorbazole C Derivatives as MNK Inhibitors through Virtual High-Throughput Screening
por: Jin, Xin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_vh7qqhe25ug3a1h72ck64vii8q