Applications of Biomaterials in 3D Cell Culture and Contributions of 3D Cell Culture to Drug Development and Basic Biomedical Research

The process of evaluating the efficacy and toxicity of drugs is important in the production of new drugs to treat diseases. Testing in humans is the most accurate method, but there are technical and ethical limitations. To overcome these limitations, various models have been developed in which respo...

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Autores principales: Park, Yujin, Huh, Kang Moo, Kang, Sun-Woong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958286/
https://www.ncbi.nlm.nih.gov/pubmed/33801273
http://dx.doi.org/10.3390/ijms22052491
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author Park, Yujin
Huh, Kang Moo
Kang, Sun-Woong
author_facet Park, Yujin
Huh, Kang Moo
Kang, Sun-Woong
author_sort Park, Yujin
collection PubMed
description The process of evaluating the efficacy and toxicity of drugs is important in the production of new drugs to treat diseases. Testing in humans is the most accurate method, but there are technical and ethical limitations. To overcome these limitations, various models have been developed in which responses to various external stimuli can be observed to help guide future trials. In particular, three-dimensional (3D) cell culture has a great advantage in simulating the physical and biological functions of tissues in the human body. This article reviews the biomaterials currently used to improve cellular functions in 3D culture and the contributions of 3D culture to cancer research, stem cell culture and drug and toxicity screening.
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spelling pubmed-79582862021-03-16 Applications of Biomaterials in 3D Cell Culture and Contributions of 3D Cell Culture to Drug Development and Basic Biomedical Research Park, Yujin Huh, Kang Moo Kang, Sun-Woong Int J Mol Sci Review The process of evaluating the efficacy and toxicity of drugs is important in the production of new drugs to treat diseases. Testing in humans is the most accurate method, but there are technical and ethical limitations. To overcome these limitations, various models have been developed in which responses to various external stimuli can be observed to help guide future trials. In particular, three-dimensional (3D) cell culture has a great advantage in simulating the physical and biological functions of tissues in the human body. This article reviews the biomaterials currently used to improve cellular functions in 3D culture and the contributions of 3D culture to cancer research, stem cell culture and drug and toxicity screening. MDPI 2021-03-02 /pmc/articles/PMC7958286/ /pubmed/33801273 http://dx.doi.org/10.3390/ijms22052491 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Park, Yujin
Huh, Kang Moo
Kang, Sun-Woong
Applications of Biomaterials in 3D Cell Culture and Contributions of 3D Cell Culture to Drug Development and Basic Biomedical Research
title Applications of Biomaterials in 3D Cell Culture and Contributions of 3D Cell Culture to Drug Development and Basic Biomedical Research
title_full Applications of Biomaterials in 3D Cell Culture and Contributions of 3D Cell Culture to Drug Development and Basic Biomedical Research
title_fullStr Applications of Biomaterials in 3D Cell Culture and Contributions of 3D Cell Culture to Drug Development and Basic Biomedical Research
title_full_unstemmed Applications of Biomaterials in 3D Cell Culture and Contributions of 3D Cell Culture to Drug Development and Basic Biomedical Research
title_short Applications of Biomaterials in 3D Cell Culture and Contributions of 3D Cell Culture to Drug Development and Basic Biomedical Research
title_sort applications of biomaterials in 3d cell culture and contributions of 3d cell culture to drug development and basic biomedical research
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958286/
https://www.ncbi.nlm.nih.gov/pubmed/33801273
http://dx.doi.org/10.3390/ijms22052491
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AT kangsunwoong applicationsofbiomaterialsin3dcellcultureandcontributionsof3dcellculturetodrugdevelopmentandbasicbiomedicalresearch

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