Inhibition of neuroinflammatory nitric oxide signaling suppresses glycation and prevents neuronal dysfunction in mouse prion disease

Several neurodegenerative diseases associated with protein misfolding (Alzheimer’s and Parkinson’s disease) exhibit oxidative and nitrergic stress following initiation of neuroinflammatory pathways. Associated nitric oxide (NO)-mediated posttranslational modifications impact upon protein functions t...

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Detalles Bibliográficos
Autores principales: Bourgognon, Julie-Myrtille, Spiers, Jereme G., Robinson, Sue W., Scheiblich, Hannah, Glynn, Paul, Ortori, Catharine, Bradley, Sophie J., Tobin, Andrew B., Steinert, Joern R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958397/
https://www.ncbi.nlm.nih.gov/pubmed/33653950
http://dx.doi.org/10.1073/pnas.2009579118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958397/
https://www.ncbi.nlm.nih.gov/pubmed/33653950
http://dx.doi.org/10.1073/pnas.2009579118

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