Cargando…
Correction for both common and rare cell types in blood is important to identify genes that correlate with age
BACKGROUND: Aging is a multifactorial process that affects multiple tissues and is characterized by changes in homeostasis over time, leading to increased morbidity. Whole blood gene expression signatures have been associated with aging and have been used to gain information on its biological mechan...
Autores principales: | Pellegrino-Coppola, Damiano, Claringbould, Annique, Stutvoet, Maartje, Boomsma, Dorret I., Ikram, M. Arfan, Slagboom, P. Eline, Westra, Harm-Jan, Franke, Lude |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958454/ https://www.ncbi.nlm.nih.gov/pubmed/33722199 http://dx.doi.org/10.1186/s12864-020-07344-w |
Ejemplares similares
-
Mendelian randomization while jointly modeling cis genetics identifies causal relationships between gene expression and lipids
por: van der Graaf, Adriaan, et al.
Publicado: (2020) -
Lipid-induced transcriptomic changes in blood link to lipid metabolism and allergic response
por: Dekkers, Koen F., et al.
Publicado: (2023) -
Functional genomics analysis identifies T and NK cell activation as a driver of epigenetic clock progression
por: Jonkman, Thomas H., et al.
Publicado: (2022) -
Genome-wide identification of directed gene networks using large-scale population genomics data
por: Luijk, René, et al.
Publicado: (2018) -
Evaluation of commonly used analysis strategies for epigenome- and transcriptome-wide association studies through replication of large-scale population studies
por: van Rooij, Jeroen, et al.
Publicado: (2019)