Pathogenic LRRK2 regulates ciliation probability upstream of tau tubulin kinase 2 via Rab10 and RILPL1 proteins

Mutations that activate LRRK2 protein kinase cause Parkinson's disease. We showed previously that Rab10 phosphorylation by LRRK2 enhances its binding to RILPL1, and together, these proteins block cilia formation in a variety of cell types, including patient derived iPS cells. We have used live-...

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Detalles Bibliográficos
Autores principales: Sobu, Yuriko, Wawro, Paulina S., Dhekne, Herschel S., Yeshaw, Wondwossen M., Pfeffer, Suzanne R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958464/
https://www.ncbi.nlm.nih.gov/pubmed/33653948
http://dx.doi.org/10.1073/pnas.2005894118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958464/
https://www.ncbi.nlm.nih.gov/pubmed/33653948
http://dx.doi.org/10.1073/pnas.2005894118

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