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Altered spontaneous brain activity in patients with diabetic optic neuropathy: A resting-state functional magnetic resonance imaging study using regional homogeneity
BACKGROUND: Diabetes is a common chronic disease. Given the increasing incidence of diabetes, more individuals are affected by diabetic optic neuropathy (DON), which results in decreased vision. Whether DON leads to abnormalities of other visual systems, including the eye, the visual cortex, and oth...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958477/ https://www.ncbi.nlm.nih.gov/pubmed/33758647 http://dx.doi.org/10.4239/wjd.v12.i3.278 |
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author | Guo, Gui-Ying Zhang, Li-Juan Li, Biao Liang, Rong-Bin Ge, Qian-Min Shu, Hui-Ye Li, Qiu-Yu Pan, Yi-Cong Pei, Chong-Gang Shao, Yi |
author_facet | Guo, Gui-Ying Zhang, Li-Juan Li, Biao Liang, Rong-Bin Ge, Qian-Min Shu, Hui-Ye Li, Qiu-Yu Pan, Yi-Cong Pei, Chong-Gang Shao, Yi |
author_sort | Guo, Gui-Ying |
collection | PubMed |
description | BACKGROUND: Diabetes is a common chronic disease. Given the increasing incidence of diabetes, more individuals are affected by diabetic optic neuropathy (DON), which results in decreased vision. Whether DON leads to abnormalities of other visual systems, including the eye, the visual cortex, and other brain regions, remains unknown. AIM: To investigate the local characteristics of spontaneous brain activity using regional homogeneity (ReHo) in patients with DON. METHODS: We matched 22 patients with DON with 22 healthy controls (HCs). All subjects underwent resting-state functional magnetic resonance imaging. The ReHo technique was used to record spontaneous changes in brain activity. Receiver operating characteristic (ROC) curves were applied to differentiate between ReHo values for patients with DON and HCs. We also assessed the correlation between Hospital Anxiety and Depression Scale scores and ReHo values in DON patients using Pearson correlation analysis. RESULTS: ReHo values of the right middle frontal gyrus (RMFG), left anterior cingulate (LAC), and superior frontal gyrus (SFG)/left frontal superior orbital gyrus (LFSO) were significantly lower in DON patients compared to HCs. Among these, the greatest difference was observed in the RMFG. The result of the ROC curves suggest that ReHo values in altered brain regions may help diagnose DON, and the RMFG and LAC ReHo values are more clinically relevant than SFG/LFSO. We also found that anxiety and depression scores of the DON group were extremely negatively correlated with the LAC ReHo values (r = -0.9336, P < 0.0001 and r = -0.8453, P < 0.0001, respectively). CONCLUSION: Three different brain regions show ReHo changes in DON patients, and these changes could serve as diagnostic and/or prognostic biomarkers to further guide the prevention and treatment of DON patients. |
format | Online Article Text |
id | pubmed-7958477 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-79584772021-03-22 Altered spontaneous brain activity in patients with diabetic optic neuropathy: A resting-state functional magnetic resonance imaging study using regional homogeneity Guo, Gui-Ying Zhang, Li-Juan Li, Biao Liang, Rong-Bin Ge, Qian-Min Shu, Hui-Ye Li, Qiu-Yu Pan, Yi-Cong Pei, Chong-Gang Shao, Yi World J Diabetes Clinical Trials Study BACKGROUND: Diabetes is a common chronic disease. Given the increasing incidence of diabetes, more individuals are affected by diabetic optic neuropathy (DON), which results in decreased vision. Whether DON leads to abnormalities of other visual systems, including the eye, the visual cortex, and other brain regions, remains unknown. AIM: To investigate the local characteristics of spontaneous brain activity using regional homogeneity (ReHo) in patients with DON. METHODS: We matched 22 patients with DON with 22 healthy controls (HCs). All subjects underwent resting-state functional magnetic resonance imaging. The ReHo technique was used to record spontaneous changes in brain activity. Receiver operating characteristic (ROC) curves were applied to differentiate between ReHo values for patients with DON and HCs. We also assessed the correlation between Hospital Anxiety and Depression Scale scores and ReHo values in DON patients using Pearson correlation analysis. RESULTS: ReHo values of the right middle frontal gyrus (RMFG), left anterior cingulate (LAC), and superior frontal gyrus (SFG)/left frontal superior orbital gyrus (LFSO) were significantly lower in DON patients compared to HCs. Among these, the greatest difference was observed in the RMFG. The result of the ROC curves suggest that ReHo values in altered brain regions may help diagnose DON, and the RMFG and LAC ReHo values are more clinically relevant than SFG/LFSO. We also found that anxiety and depression scores of the DON group were extremely negatively correlated with the LAC ReHo values (r = -0.9336, P < 0.0001 and r = -0.8453, P < 0.0001, respectively). CONCLUSION: Three different brain regions show ReHo changes in DON patients, and these changes could serve as diagnostic and/or prognostic biomarkers to further guide the prevention and treatment of DON patients. Baishideng Publishing Group Inc 2021-03-15 2021-03-15 /pmc/articles/PMC7958477/ /pubmed/33758647 http://dx.doi.org/10.4239/wjd.v12.i3.278 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Clinical Trials Study Guo, Gui-Ying Zhang, Li-Juan Li, Biao Liang, Rong-Bin Ge, Qian-Min Shu, Hui-Ye Li, Qiu-Yu Pan, Yi-Cong Pei, Chong-Gang Shao, Yi Altered spontaneous brain activity in patients with diabetic optic neuropathy: A resting-state functional magnetic resonance imaging study using regional homogeneity |
title | Altered spontaneous brain activity in patients with diabetic optic neuropathy: A resting-state functional magnetic resonance imaging study using regional homogeneity |
title_full | Altered spontaneous brain activity in patients with diabetic optic neuropathy: A resting-state functional magnetic resonance imaging study using regional homogeneity |
title_fullStr | Altered spontaneous brain activity in patients with diabetic optic neuropathy: A resting-state functional magnetic resonance imaging study using regional homogeneity |
title_full_unstemmed | Altered spontaneous brain activity in patients with diabetic optic neuropathy: A resting-state functional magnetic resonance imaging study using regional homogeneity |
title_short | Altered spontaneous brain activity in patients with diabetic optic neuropathy: A resting-state functional magnetic resonance imaging study using regional homogeneity |
title_sort | altered spontaneous brain activity in patients with diabetic optic neuropathy: a resting-state functional magnetic resonance imaging study using regional homogeneity |
topic | Clinical Trials Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958477/ https://www.ncbi.nlm.nih.gov/pubmed/33758647 http://dx.doi.org/10.4239/wjd.v12.i3.278 |
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