Cargando…

Sexual Difference Matters: Females with High Microsatellite Instability Show Increased Survival after Neoadjuvant Chemotherapy in Gastric Cancer

SIMPLE SUMMARY: Here we report a sex- and age-specific analysis of 717 patients with gastric/gastro-esophageal adenocarcinomas treated with or without neoadjuvant chemotherapy (CTx) regarding overall survival (OS) and response to CTx. The analysis was also performed in molecular subtypes determined...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kohlruss, Meike, Ott, Katja, Grosser, Bianca, Jesinghaus, Moritz, Slotta-Huspenina, Julia, Novotny, Alexander, Hapfelmeier, Alexander, Schmidt, Thomas, Gaida, Matthias M., Weichert, Wilko, Keller, Gisela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958600/ https://www.ncbi.nlm.nih.gov/pubmed/33801374 http://dx.doi.org/10.3390/cancers13051048

Ejemplares similares

A microsatellite based multiplex PCR method for the detection of chromosomal instability in gastric cancer
por: Kohlruss, Meike, et al.
Publicado: (2018)

Elevated microsatellite instability at selected tetranucleotide (EMAST) repeats in gastric cancer: a distinct microsatellite instability type with potential clinical impact?
por: Herz, Anna‐Lina, et al.
Publicado: (2022)

Microsatellite instability and sex-specific differences of survival in gastric cancer after neoadjuvant chemotherapy without and with taxane: An observational study in real world patients
por: Hiltner, Theresa, et al.
Publicado: (2023)

Diverse ‘just-right’ levels of chromosomal instability and their clinical implications in neoadjuvant treated gastric cancer
por: Kohlruss, Meike, et al.
Publicado: (2021)

Prognostic implication of molecular subtypes and response to neoadjuvant chemotherapy in 760 gastric carcinomas: role of Epstein–Barr virus infection and high‐ and low‐microsatellite instability
por: Kohlruss, Meike, et al.
Publicado: (2019)

Impact of Tumor Localization and Molecular Subtypes on the Prognostic and Predictive Significance of p53 Expression in Gastric Cancer
por: Grosser, Bianca, et al.
Publicado: (2020)

Significant Tumor Regression after Neoadjuvant Chemotherapy in Gastric Cancer, but Poor Survival of the Patient? Role of MHC Class I Alterations
por: Hiltner, Theresa, et al.
Publicado: (2023)

Post‐neoadjuvant assessment of tumour budding according to ITBCC subgroups delivers stage‐ and regression‐grade independent prognostic information in intestinal‐type gastric adenocarcinoma
por: Jesinghaus, Moritz, et al.
Publicado: (2022)

Clinical Significance of NOTCH1 and NOTCH2 Expression in Gastric Carcinomas: An Immunohistochemical Study
por: Bauer, Lukas, et al.
Publicado: (2015)

Independent Tissue-Based Biomarkers in Endometrioid Endometrial Cancer: Tumor Budding in Microsatellite Instability and WHO Grading in Copy-Number-Low Patients
por: Stögbauer, Fabian, et al.
Publicado: (2023)

Significance of tumour regression in lymph node metastases of gastric and gastro‐oesophageal junction adenocarcinomas
por: Reim, Daniel, et al.
Publicado: (2020)

MicroRNA expression profiling for the prediction of resistance to neoadjuvant radiochemotherapy in squamous cell carcinoma of the esophagus
por: Slotta-Huspenina, Julia, et al.
Publicado: (2018)

Comparison of neoadjuvant chemoradiation with carboplatin/ paclitaxel or cisplatin/ 5-fluoruracil in patients with squamous cell carcinoma of the esophagus
por: Münch, Stefan, et al.
Publicado: (2017)

Correction to: MicroRNA expression profiling for the prediction of resistance to neoadjuvant radiochemotherapy in squamous cell carcinoma of the esophagus
por: Slotta-Huspenina, Julia, et al.
Publicado: (2018)

Increased intraepithelial CD3+ T-lymphocytes and high PD-L1 expression on tumor cells are associated with a favorable prognosis in esophageal squamous cell carcinoma and allow prognostic immunogenic subgrouping
por: Jesinghaus, Moritz, et al.
Publicado: (2017)

Expression Profiling of Stem Cell-Related Genes in Neoadjuvant-Treated Gastric Cancer: A NOTCH2, GSK3B and β-catenin Gene Signature Predicts Survival
por: Bauer, Lukas, et al.
Publicado: (2012)

UICC Staging after Neoadjuvant/Perioperative Chemotherapy Reveals No Significant Survival Differences Compared to Primary Surgery for Locally Advanced Gastric Cancer
por: Dimpel, Rebekka, et al.
Publicado: (2022)

Significance of Lauren Classification in Patients Undergoing Neoadjuvant/Perioperative Chemotherapy for Locally Advanced Gastric or Gastroesophageal Junction Cancers—Analysis from a Large Single Center Cohort in Germany
por: Schirren, Rebekka, et al.
Publicado: (2021)

Loss of CDX2 in colorectal cancer is associated with histopathologic subtypes and microsatellite instability but is prognostically inferior to hematoxylin–eosin-based morphologic parameters from the WHO classification
por: Konukiewitz, Björn, et al.
Publicado: (2021)

Neoadjuvant versus definitive chemoradiation in patients with squamous cell carcinoma of the esophagus
por: Münch, Stefan, et al.
Publicado: (2019)

Novel Histologic Categorization Based on Lauren Histotypes Conveys Prognostic Information for Gastroesophageal Junction Cancers—Analysis from a Large Single Center Cohort in Germany
por: Schirren, Rebekka, et al.
Publicado: (2021)

Development and validation of deep learning classifiers to detect Epstein-Barr virus and microsatellite instability status in gastric cancer: a retrospective multicentre cohort study
por: Muti, Hannah Sophie, et al.
Publicado: (2021)

Combination treatment of bilateral periocular sebaceous carcinomas with microsatellite instability with neoadjuvant pembrolizumab and Mohs surgery
por: Woods, Alexander D., et al.
Publicado: (2022)

A retrospective comparative exploratory study on two Methylentetrahydrofolate Reductase (MTHFR) polymorphisms in esophagogastric cancer: the A1298C MTHFR polymorphism is an independent prognostic factor only in neoadjuvantly treated gastric cancer patients
por: Blank, Susanne, et al.
Publicado: (2014)

Pharmacoproteomic characterisation of human colon and rectal cancer
por: Frejno, Martin, et al.
Publicado: (2017)

Editorial: Microsatellite and microsatellite instability
por: How-Kit, Alexandre, et al.
Publicado: (2023)

Association between microsatellite instability and tumor response to neoadjuvant chemoradiotherapy for rectal cancer
por: Lee, Soo Young, et al.
Publicado: (2022)

Evolutionary and immune microenvironment dynamics during neoadjuvant treatment of oesophagael adenocarcinoma
por: Barroux, Melissa, et al.
Publicado: (2023)

Non-Hodgkin Lymphoma Secondary to Hodgkin Lymphoma in an Adult Patient With Nijmegen Breakage Syndrome
por: Braitsch, Krischan, et al.
Publicado: (2018)

Association between HSP90 and Her2 in Gastric and Gastroesophageal Carcinomas
por: Berezowska, Sabina, et al.
Publicado: (2013)

Whole Exome Sequencing of Biliary Tubulopapillary Neoplasms Reveals Common Mutations in Chromatin Remodeling Genes
por: Gross, Claudia, et al.
Publicado: (2021)

A specific expression profile of heat-shock proteins and glucose-regulated proteins is associated with response to neoadjuvant chemotherapy in oesophageal adenocarcinomas
por: Slotta-Huspenina, J, et al.
Publicado: (2013)

The immunologic tumor microenvironment in endometrioid endometrial cancer in the morphomolecular context: mutual correlations and prognostic impact depending on molecular alterations
por: Willvonseder, Barbara, et al.
Publicado: (2020)

A specific expression profile of LC3B and p62 is associated with nonresponse to neoadjuvant chemotherapy in esophageal adenocarcinomas
por: Adams, Olivia, et al.
Publicado: (2018)

First prospective outcome data for the second-generation multigene test Endopredict in ER-positive/HER2-negative breast cancer
por: Ettl, Johannes, et al.
Publicado: (2020)

Correction: A specific expression profile of LC3B and p62 is associated with nonresponse to neoadjuvant chemotherapy in esophageal adenocarcinomas
por: Adams, Olivia, et al.
Publicado: (2019)

Microsatellite instability in ovarian neoplasms.
por: King, B. L., et al.
Publicado: (1995)

Microsatellite instability in colorectal cancer
por: Horvat, Matej, et al.
Publicado: (2011)

Microsatellite instability in colorectal cancer
por: Nojadeh, Jafar Nouri, et al.
Publicado: (2018)

Microsatellite instability in colorectal cancer
por: Gian, Luigi de’Angelis, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_pv5fhjg62s0e3uovd34u0s4p3t