CD28 Co-Stimulus Achieves Superior CAR T Cell Effector Function against Solid Tumors Than 4-1BB Co-Stimulus

SIMPLE SUMMARY: Efficient trafficking and survival of CAR T cells within the hostile tumor microenvironment are important prerequisites for potent solid tumor attack that have not yet been achieved. We deployed monospecific murine instead of polyclonal human T cells for CAR T cell generation to eval...

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Detalles Bibliográficos
Autores principales: Textor, Ana, Grunewald, Laura, Anders, Kathleen, Klaus, Anika, Schwiebert, Silke, Winkler, Annika, Stecklum, Maria, Rolff, Jana, Henssen, Anton G., Höpken, Uta E., Eggert, Angelika, Schulte, Johannes H., Jensen, Michael C., Blankenstein, Thomas, Künkele, Annette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958604/
https://www.ncbi.nlm.nih.gov/pubmed/33801448
http://dx.doi.org/10.3390/cancers13051050

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