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Spontaneous Breathing and Evolving Phenotypes of Lung Damage in Patients with COVID-19: Review of Current Evidence and Forecast of a New Scenario
The mechanisms of acute respiratory failure other than inflammation and complicating the SARS-CoV-2 infection are still far from being fully understood, thus challenging the management of COVID-19 patients in the critical care setting. In this unforeseen scenario, the role of an individual’s excessi...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958611/ https://www.ncbi.nlm.nih.gov/pubmed/33801368 http://dx.doi.org/10.3390/jcm10050975 |
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author | Tonelli, Roberto Marchioni, Alessandro Tabbì, Luca Fantini, Riccardo Busani, Stefano Castaniere, Ivana Andrisani, Dario Gozzi, Filippo Bruzzi, Giulia Manicardi, Linda Demurtas, Jacopo Andreani, Alessandro Cappiello, Gaia Francesca Samarelli, Anna Valeria Clini, Enrico |
author_facet | Tonelli, Roberto Marchioni, Alessandro Tabbì, Luca Fantini, Riccardo Busani, Stefano Castaniere, Ivana Andrisani, Dario Gozzi, Filippo Bruzzi, Giulia Manicardi, Linda Demurtas, Jacopo Andreani, Alessandro Cappiello, Gaia Francesca Samarelli, Anna Valeria Clini, Enrico |
author_sort | Tonelli, Roberto |
collection | PubMed |
description | The mechanisms of acute respiratory failure other than inflammation and complicating the SARS-CoV-2 infection are still far from being fully understood, thus challenging the management of COVID-19 patients in the critical care setting. In this unforeseen scenario, the role of an individual’s excessive spontaneous breathing may acquire critical importance, being one potential and important driver of lung injury and disease progression. The consequences of this acute lung damage may impair lung structure, forecasting the model of a fragile respiratory system. This perspective article aims to analyze the progression of injured lung phenotypes across the SARS-CoV-2 induced respiratory failure, pointing out the role of spontaneous breathing and also tackling the specific respiratory/ventilatory strategy required by the fragile lung type. |
format | Online Article Text |
id | pubmed-7958611 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79586112021-03-16 Spontaneous Breathing and Evolving Phenotypes of Lung Damage in Patients with COVID-19: Review of Current Evidence and Forecast of a New Scenario Tonelli, Roberto Marchioni, Alessandro Tabbì, Luca Fantini, Riccardo Busani, Stefano Castaniere, Ivana Andrisani, Dario Gozzi, Filippo Bruzzi, Giulia Manicardi, Linda Demurtas, Jacopo Andreani, Alessandro Cappiello, Gaia Francesca Samarelli, Anna Valeria Clini, Enrico J Clin Med Review The mechanisms of acute respiratory failure other than inflammation and complicating the SARS-CoV-2 infection are still far from being fully understood, thus challenging the management of COVID-19 patients in the critical care setting. In this unforeseen scenario, the role of an individual’s excessive spontaneous breathing may acquire critical importance, being one potential and important driver of lung injury and disease progression. The consequences of this acute lung damage may impair lung structure, forecasting the model of a fragile respiratory system. This perspective article aims to analyze the progression of injured lung phenotypes across the SARS-CoV-2 induced respiratory failure, pointing out the role of spontaneous breathing and also tackling the specific respiratory/ventilatory strategy required by the fragile lung type. MDPI 2021-03-02 /pmc/articles/PMC7958611/ /pubmed/33801368 http://dx.doi.org/10.3390/jcm10050975 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tonelli, Roberto Marchioni, Alessandro Tabbì, Luca Fantini, Riccardo Busani, Stefano Castaniere, Ivana Andrisani, Dario Gozzi, Filippo Bruzzi, Giulia Manicardi, Linda Demurtas, Jacopo Andreani, Alessandro Cappiello, Gaia Francesca Samarelli, Anna Valeria Clini, Enrico Spontaneous Breathing and Evolving Phenotypes of Lung Damage in Patients with COVID-19: Review of Current Evidence and Forecast of a New Scenario |
title | Spontaneous Breathing and Evolving Phenotypes of Lung Damage in Patients with COVID-19: Review of Current Evidence and Forecast of a New Scenario |
title_full | Spontaneous Breathing and Evolving Phenotypes of Lung Damage in Patients with COVID-19: Review of Current Evidence and Forecast of a New Scenario |
title_fullStr | Spontaneous Breathing and Evolving Phenotypes of Lung Damage in Patients with COVID-19: Review of Current Evidence and Forecast of a New Scenario |
title_full_unstemmed | Spontaneous Breathing and Evolving Phenotypes of Lung Damage in Patients with COVID-19: Review of Current Evidence and Forecast of a New Scenario |
title_short | Spontaneous Breathing and Evolving Phenotypes of Lung Damage in Patients with COVID-19: Review of Current Evidence and Forecast of a New Scenario |
title_sort | spontaneous breathing and evolving phenotypes of lung damage in patients with covid-19: review of current evidence and forecast of a new scenario |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958611/ https://www.ncbi.nlm.nih.gov/pubmed/33801368 http://dx.doi.org/10.3390/jcm10050975 |
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