Cargando…

Silencing CDCA8 Suppresses Hepatocellular Carcinoma Growth and Stemness via Restoration of ATF3 Tumor Suppressor and Inactivation of AKT/β–Catenin Signaling

SIMPLE SUMMARY: Although the overexpression of CDCA8 is frequently observed in hepatocellular carcinoma (HCC) tissues, the functions of CDCA8 during HCC development remain to be clarified. The aim of our study was to investigate if targeting CDCA8 could affect liver tumor phenotypes in vitro and in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jeon, Taewon, Ko, Min Ji, Seo, Yu-Ri, Jung, Soo-Jung, Seo, Daekwan, Park, So-Young, Park, Keon Uk, Kim, Kwang Seok, Kim, Mikyung, Seo, Ji Hae, Park, In-Chul, Kim, Min-Ji, Bae, Jae-Hoon, Song, Dae-Kyu, Cho, Chi Heum, Lee, Jae-Ho, Lee, Yun-Han
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958635/ https://www.ncbi.nlm.nih.gov/pubmed/33801424 http://dx.doi.org/10.3390/cancers13051055

Ejemplares similares

RPL17 Promotes Colorectal Cancer Proliferation and Stemness through ERK and NEK2/β-catenin Signaling Pathways
por: Ko, Min Ji, et al.
Publicado: (2022)

β-Escin overcomes trastuzumab resistance in HER2-positive breast cancer by targeting cancer stem-like features
por: Park, Soeun, et al.
Publicado: (2022)

In Situ Supramolecular Gel Formed by Cyclohexane Diamine with Aldehyde Derivative
por: Park, Jae-Hyeon, et al.
Publicado: (2022)

Suppression of TNBC metastasis by doxazosin, a novel dual inhibitor of c-MET/EGFR
por: Kim, Seongjae, et al.
Publicado: (2023)

RPL27 contributes to colorectal cancer proliferation and stemness via PLK1 signaling
por: Park, So-Young, et al.
Publicado: (2023)

Understanding of the functional role(s) of the Activating Transcription Factor 4(ATF4) in HIV regulation and production
por: Lee, Seong-Deok, et al.
Publicado: (2018)

Ebastine impairs metastatic spread in triple-negative breast cancer by targeting focal adhesion kinase
por: Seo, Juyeon, et al.
Publicado: (2023)

Is routine nasogastric tube insertion necessary in pancreaticoduodenectomy?
por: Choi, Yoon Young, et al.
Publicado: (2011)

White LED Lighting Increases the Root Productivity of Panax ginseng C. A. Meyer in a Hydroponic Cultivation System of a Plant Factory
por: Kim, Se-Hee, et al.
Publicado: (2023)

Tumor-Suppressive Effect of Metformin via the Regulation of M2 Macrophages and Myeloid-Derived Suppressor Cells in the Tumor Microenvironment of Colorectal Cancer
por: Kang, Joyeon, et al.
Publicado: (2022)

Induction of DR5-Dependent Apoptosis by PGA(2) through ATF4-CHOP Pathway
por: Park, Kyeong-Min, et al.
Publicado: (2022)

Effect of School-Based Social Skills Training Program on Peer Relationships: Preliminary Study
por: Roh, Hong-Shik, et al.
Publicado: (2018)

Investigation of the dorsolateral branch of the posterior intercostal artery for use as the pedicle of a free flap: A cadaveric study and case series
por: Nam, Su Bong, et al.
Publicado: (2019)

Gut Microbial Profile Changes in Patients with Gallbladder Stones after UDCA/CDCA Treatment
por: Lee, Jungnam, et al.
Publicado: (2023)

Chronic Ethanol Consumption Inhibits Glucokinase Transcriptional Activity by Atf3 and Triggers Metabolic Syndrome in Vivo
por: Kim, Ji Yeon, et al.
Publicado: (2014)

Antiviral activity of Bifidobacterium adolescentis SPM1605 against Coxsackievirus B3
por: Kim, Min Ji, et al.
Publicado: (2014)

Quantitative Analysis in Cervical Spinal Cord Injury Patients Using Diffusion Tensor Imaging and Tractography
por: Park, Geun Seok, et al.
Publicado: (2022)

A novel HSP90 inhibitor targeting the C-terminal domain attenuates trastuzumab resistance in HER2-positive breast cancer
por: Park, Jung Min, et al.
Publicado: (2020)

Early Exotic Vegetation Development Is Affected by Vine Plants and Bird Activity at Rapidly Exposed Floodplains in South Korea
por: Park, Jae-Hoon, et al.
Publicado: (2023)

Cigarette Smoke-Induced Reactive Oxygen Species Formation: A Concise Review
por: Seo, Yoon-Seok, et al.
Publicado: (2023)

Primary malignant melanoma of the lacrimal sac: A case report
por: Nam, Ji Hyung, et al.
Publicado: (2006)

Antiviral Activities of High Energy E-Beam Induced Copper Nanoparticles against H1N1 Influenza Virus
por: Ha, Taesung, et al.
Publicado: (2022)

Morphological studies of fly puparia (Diptera: Calliphoridae) in the soil from a Joseon Dynasty grave in Korea
por: Lee, In-Yong, et al.
Publicado: (2023)

The Wnt/β-catenin signaling pathway regulates the development of airway remodeling in patients with asthma
por: Kwak, Hyun Jung, et al.
Publicado: (2015)

3-Hydroxybutyrate Ameliorates the Progression of Diabetic Nephropathy
por: Jung, Jeeyoun, et al.
Publicado: (2022)

Bone-Targeting AAV-Mediated Gene Silencing in Osteoclasts for Osteoporosis Therapy
por: Yang, Yeon-Suk, et al.
Publicado: (2020)

The complete chloroplast genome of Bupleurum euphorbioides, a traditional medicinal plant
por: Park, Seong-Sik, et al.
Publicado: (2021)

The complete chloroplast genome of Bupleurum euphorbioides, a traditional medicinal plant
por: Park, Seong-Sik, et al.
Publicado: (2021)

Long-term sentinel surveillance of enteroviruses in Gwangju, South Korea, 2011–2020
por: Kim, Min Ji, et al.
Publicado: (2023)

Correction: Adiponectin Suppresses UVB-Induced Premature Senescence and hBD2 Overexpression in Human Keratinocytes
por: Kim, MinJeong, et al.
Publicado: (2016)

Adiponectin Suppresses UVB-Induced Premature Senescence and hBD2 Overexpression in Human Keratinocytes
por: Kim, MinJeong, et al.
Publicado: (2016)

Association between Vestibular Function and Hearing Outcome in Idiopathic Sudden Sensorineural Hearing Loss
por: Lee, Ho-Seok, et al.
Publicado: (2014)

Human MicroRNAs Attenuate the Expression of Immediate Early Proteins and HCMV Replication during Lytic and Latent Infection in Connection with Enhancement of Phosphorylated RelA/p65 (Serine 536) That Binds to MIEP
por: Hong, Yeon-Mi, et al.
Publicado: (2022)

Detection of Borrelia miyamotoi in Ixodes nipponensis in Korea
por: Kim, Choon Mee, et al.
Publicado: (2019)

Treadmill exercise activates ATF3 and ERK1/2 downstream molecules to facilitate axonal regrowth after sciatic nerve injury
por: Kim, Ji-Eun, et al.
Publicado: (2020)

Sequential transfection of RUNX2/SP7 and ATF4 coated onto dexamethasone-loaded nanospheres enhances osteogenesis
por: Kim, Hye Jin, et al.
Publicado: (2018)

Thrombosis patterns and clinical outcome of COVID-19 vaccine-induced immune thrombotic thrombocytopenia: A Systematic Review and Meta-Analysis
por: Kim, Ah Young, et al.
Publicado: (2022)

Corrigendum to ‘Thrombosis patterns and clinical outcome of COVID-19 vaccine-induced immune thrombotic thrombocytopenia: A Systematic Review and Meta-Analysis’ International Journal of Infectious Diseases, Volume 119, June 2022, Page 130-139
por: Kim, Ah Young, et al.
Publicado: (2022)

The C-terminal HSP90 inhibitor NCT-58 kills trastuzumab-resistant breast cancer stem-like cells
por: Park, Soeun, et al.
Publicado: (2021)

Pinealectomy increases thermogenesis and decreases lipogenesis
por: Kim, Mikyung, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_qbb1jah9dh38lnhg9sulrmngef