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Gut microbiota-mediated lysophosphatidylcholine generation promotes colitis in intestinal epithelium-specific Fut2 deficiency

BACKGROUND AND AIMS: Previous study disclosed Fucosyltransferase 2 (Fut2) gene as a IBD risk locus. This study aimed to explore the mechanism of Fut2 in IBD susceptibility and to propose a new strategy for the treatment of IBD. METHODS: Intestinal epithelium-specific Fut2 knockout (Fut2(△IEC)) mice...

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Detalles Bibliográficos
Autores principales:	Tang, Xuelian, Wang, Weijun, Hong, Gaichao, Duan, Caihan, Zhu, Siran, Tian, Yuen, Han, Chaoqun, Qian, Wei, Lin, Rong, Hou, Xiaohua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958775/ https://www.ncbi.nlm.nih.gov/pubmed/33722220 http://dx.doi.org/10.1186/s12929-021-00711-z

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