Dynamics of Human Immunodeficiency Virus-1 Genetic Diversification During Acute Infection

We analyzed human immunodeficiency virus envelope diversity in 98 acute infections. The within-host genetic diversity, divergence from transmitted/founder (T/F) strain, and the observed frequency of multiple T/F infections increased with Fiebig stage. These data identify rapid viral dynamics during...

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Detalles Bibliográficos
Autores principales: Song, Hongshuo, Bose, Meera, Pinyakorn, Suteeraporn, Sanders-Buell, Eric, O’Sullivan, Anne Marie, Silas, Daniel, Trichavaroj, Rapee, Nuntapinit, Bessara, Pham, Phuc T, Akapirat, Siriwat, Kroon, Eugène, de Souza, Mark, Gramzinski, Robert, Michael, Nelson L, Robb, Merlin L, Vasan, Sandhya, Tovanabutra, Sodsai, Ananworanich, Jintanat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958800/
https://www.ncbi.nlm.nih.gov/pubmed/33748316
http://dx.doi.org/10.1093/ofid/ofaa429
Descripción
Sumario:We analyzed human immunodeficiency virus envelope diversity in 98 acute infections. The within-host genetic diversity, divergence from transmitted/founder (T/F) strain, and the observed frequency of multiple T/F infections increased with Fiebig stage. These data identify rapid viral dynamics during acute infection with implications for clinical trials conducted in this setting.

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