Dynamics of Human Immunodeficiency Virus-1 Genetic Diversification During Acute Infection

We analyzed human immunodeficiency virus envelope diversity in 98 acute infections. The within-host genetic diversity, divergence from transmitted/founder (T/F) strain, and the observed frequency of multiple T/F infections increased with Fiebig stage. These data identify rapid viral dynamics during...

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Autores principales: Song, Hongshuo, Bose, Meera, Pinyakorn, Suteeraporn, Sanders-Buell, Eric, O’Sullivan, Anne Marie, Silas, Daniel, Trichavaroj, Rapee, Nuntapinit, Bessara, Pham, Phuc T, Akapirat, Siriwat, Kroon, Eugène, de Souza, Mark, Gramzinski, Robert, Michael, Nelson L, Robb, Merlin L, Vasan, Sandhya, Tovanabutra, Sodsai, Ananworanich, Jintanat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958800/
https://www.ncbi.nlm.nih.gov/pubmed/33748316
http://dx.doi.org/10.1093/ofid/ofaa429
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author Song, Hongshuo
Bose, Meera
Pinyakorn, Suteeraporn
Sanders-Buell, Eric
O’Sullivan, Anne Marie
Silas, Daniel
Trichavaroj, Rapee
Nuntapinit, Bessara
Pham, Phuc T
Akapirat, Siriwat
Kroon, Eugène
de Souza, Mark
Gramzinski, Robert
Michael, Nelson L
Robb, Merlin L
Vasan, Sandhya
Tovanabutra, Sodsai
Ananworanich, Jintanat
author_facet Song, Hongshuo
Bose, Meera
Pinyakorn, Suteeraporn
Sanders-Buell, Eric
O’Sullivan, Anne Marie
Silas, Daniel
Trichavaroj, Rapee
Nuntapinit, Bessara
Pham, Phuc T
Akapirat, Siriwat
Kroon, Eugène
de Souza, Mark
Gramzinski, Robert
Michael, Nelson L
Robb, Merlin L
Vasan, Sandhya
Tovanabutra, Sodsai
Ananworanich, Jintanat
author_sort Song, Hongshuo
collection PubMed
description We analyzed human immunodeficiency virus envelope diversity in 98 acute infections. The within-host genetic diversity, divergence from transmitted/founder (T/F) strain, and the observed frequency of multiple T/F infections increased with Fiebig stage. These data identify rapid viral dynamics during acute infection with implications for clinical trials conducted in this setting.
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spelling pubmed-79588002021-03-18 Dynamics of Human Immunodeficiency Virus-1 Genetic Diversification During Acute Infection Song, Hongshuo Bose, Meera Pinyakorn, Suteeraporn Sanders-Buell, Eric O’Sullivan, Anne Marie Silas, Daniel Trichavaroj, Rapee Nuntapinit, Bessara Pham, Phuc T Akapirat, Siriwat Kroon, Eugène de Souza, Mark Gramzinski, Robert Michael, Nelson L Robb, Merlin L Vasan, Sandhya Tovanabutra, Sodsai Ananworanich, Jintanat Open Forum Infect Dis Brief Reports We analyzed human immunodeficiency virus envelope diversity in 98 acute infections. The within-host genetic diversity, divergence from transmitted/founder (T/F) strain, and the observed frequency of multiple T/F infections increased with Fiebig stage. These data identify rapid viral dynamics during acute infection with implications for clinical trials conducted in this setting. Oxford University Press 2020-09-12 /pmc/articles/PMC7958800/ /pubmed/33748316 http://dx.doi.org/10.1093/ofid/ofaa429 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Reports
Song, Hongshuo
Bose, Meera
Pinyakorn, Suteeraporn
Sanders-Buell, Eric
O’Sullivan, Anne Marie
Silas, Daniel
Trichavaroj, Rapee
Nuntapinit, Bessara
Pham, Phuc T
Akapirat, Siriwat
Kroon, Eugène
de Souza, Mark
Gramzinski, Robert
Michael, Nelson L
Robb, Merlin L
Vasan, Sandhya
Tovanabutra, Sodsai
Ananworanich, Jintanat
Dynamics of Human Immunodeficiency Virus-1 Genetic Diversification During Acute Infection
title Dynamics of Human Immunodeficiency Virus-1 Genetic Diversification During Acute Infection
title_full Dynamics of Human Immunodeficiency Virus-1 Genetic Diversification During Acute Infection
title_fullStr Dynamics of Human Immunodeficiency Virus-1 Genetic Diversification During Acute Infection
title_full_unstemmed Dynamics of Human Immunodeficiency Virus-1 Genetic Diversification During Acute Infection
title_short Dynamics of Human Immunodeficiency Virus-1 Genetic Diversification During Acute Infection
title_sort dynamics of human immunodeficiency virus-1 genetic diversification during acute infection
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958800/
https://www.ncbi.nlm.nih.gov/pubmed/33748316
http://dx.doi.org/10.1093/ofid/ofaa429
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