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Vaspin (but not neuropeptide B or neuropeptide W) as a possible predictor of body weight normalization in anorexia nervosa
INTRODUCTION: The aim of the study was to evaluate the correlation between the nutritional status of patients with anorexia nervosa (AN) and levels of vaspin (VASP), neuropeptide B (NPB), neuropeptide W (NPW) and total antioxidant status (TAS). MATERIAL AND METHODS: Ninety serum samples collected fr...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7959059/ https://www.ncbi.nlm.nih.gov/pubmed/33747273 http://dx.doi.org/10.5114/aoms.2018.74969 |
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author | Grzelak, Teresa Tyszkiewicz-Nwafor, Marta Dutkiewicz, Agata Mikulska, Aniceta Ada Dmitrzak-Weglarz, Monika Slopien, Agnieszka Czyzewska, Krystyna Paszynska, Elzbieta |
author_facet | Grzelak, Teresa Tyszkiewicz-Nwafor, Marta Dutkiewicz, Agata Mikulska, Aniceta Ada Dmitrzak-Weglarz, Monika Slopien, Agnieszka Czyzewska, Krystyna Paszynska, Elzbieta |
author_sort | Grzelak, Teresa |
collection | PubMed |
description | INTRODUCTION: The aim of the study was to evaluate the correlation between the nutritional status of patients with anorexia nervosa (AN) and levels of vaspin (VASP), neuropeptide B (NPB), neuropeptide W (NPW) and total antioxidant status (TAS). MATERIAL AND METHODS: Ninety serum samples collected from 30 teenage female patients during the acute stage of AN and 30 healthy persons (CONTR) were subjected to biochemical analysis; patients with AN were examined at the beginning of the study (AN-I) and after hospitalization (AN-II), as a result of which partial stabilization of anthropometric measurements was achieved (an increase of body mass index (BMI) by 3.5 kg/m(2)). RESULTS: Vaspin levels dropped at the end of the hospitalization (compared to AN-I, p < 0.05), achieving values comparable to the CONTR; moreover there was a positive correlation between VASP level and the achieved body weight in AN-II (p < 0.05). Positive correlations were also noted with regard to VASP vs. NPB in AN-I (p < 0.02) (and AN-II, p < 0.013), as well as in the case of VASP vs. NPW in the same groups (p < 0.02 and p < 0.015, respectively). NPB concentration was higher in AN-I (p < 0.05) and AN-II (p < 0.018) than in CONTR, whereas there were no differences (p > 0.05) with regard to levels of VASP, NPW, or TAS. CONCLUSIONS: The high level of NPB despite treatment and normalization of VASP level may suggest that there are chronic neuroendocrine disorders at play in anorexia nervosa. |
format | Online Article Text |
id | pubmed-7959059 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-79590592021-03-19 Vaspin (but not neuropeptide B or neuropeptide W) as a possible predictor of body weight normalization in anorexia nervosa Grzelak, Teresa Tyszkiewicz-Nwafor, Marta Dutkiewicz, Agata Mikulska, Aniceta Ada Dmitrzak-Weglarz, Monika Slopien, Agnieszka Czyzewska, Krystyna Paszynska, Elzbieta Arch Med Sci Clinical Research INTRODUCTION: The aim of the study was to evaluate the correlation between the nutritional status of patients with anorexia nervosa (AN) and levels of vaspin (VASP), neuropeptide B (NPB), neuropeptide W (NPW) and total antioxidant status (TAS). MATERIAL AND METHODS: Ninety serum samples collected from 30 teenage female patients during the acute stage of AN and 30 healthy persons (CONTR) were subjected to biochemical analysis; patients with AN were examined at the beginning of the study (AN-I) and after hospitalization (AN-II), as a result of which partial stabilization of anthropometric measurements was achieved (an increase of body mass index (BMI) by 3.5 kg/m(2)). RESULTS: Vaspin levels dropped at the end of the hospitalization (compared to AN-I, p < 0.05), achieving values comparable to the CONTR; moreover there was a positive correlation between VASP level and the achieved body weight in AN-II (p < 0.05). Positive correlations were also noted with regard to VASP vs. NPB in AN-I (p < 0.02) (and AN-II, p < 0.013), as well as in the case of VASP vs. NPW in the same groups (p < 0.02 and p < 0.015, respectively). NPB concentration was higher in AN-I (p < 0.05) and AN-II (p < 0.018) than in CONTR, whereas there were no differences (p > 0.05) with regard to levels of VASP, NPW, or TAS. CONCLUSIONS: The high level of NPB despite treatment and normalization of VASP level may suggest that there are chronic neuroendocrine disorders at play in anorexia nervosa. Termedia Publishing House 2018-04-09 /pmc/articles/PMC7959059/ /pubmed/33747273 http://dx.doi.org/10.5114/aoms.2018.74969 Text en Copyright: © 2018 Termedia & Banach http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | Clinical Research Grzelak, Teresa Tyszkiewicz-Nwafor, Marta Dutkiewicz, Agata Mikulska, Aniceta Ada Dmitrzak-Weglarz, Monika Slopien, Agnieszka Czyzewska, Krystyna Paszynska, Elzbieta Vaspin (but not neuropeptide B or neuropeptide W) as a possible predictor of body weight normalization in anorexia nervosa |
title | Vaspin (but not neuropeptide B or neuropeptide W) as a possible predictor of body weight normalization in anorexia nervosa |
title_full | Vaspin (but not neuropeptide B or neuropeptide W) as a possible predictor of body weight normalization in anorexia nervosa |
title_fullStr | Vaspin (but not neuropeptide B or neuropeptide W) as a possible predictor of body weight normalization in anorexia nervosa |
title_full_unstemmed | Vaspin (but not neuropeptide B or neuropeptide W) as a possible predictor of body weight normalization in anorexia nervosa |
title_short | Vaspin (but not neuropeptide B or neuropeptide W) as a possible predictor of body weight normalization in anorexia nervosa |
title_sort | vaspin (but not neuropeptide b or neuropeptide w) as a possible predictor of body weight normalization in anorexia nervosa |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7959059/ https://www.ncbi.nlm.nih.gov/pubmed/33747273 http://dx.doi.org/10.5114/aoms.2018.74969 |
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