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Preclinical Characterization of Mobocertinib Highlights the Putative Therapeutic Window of This Novel EGFR Inhibitor to EGFR Exon 20 Insertion Mutations

INTRODUCTION: EGFR exon 20 insertion mutations account for 10% of all EGFR mutations and are mostly insensitive to approved EGFR tyrosine kinase inhibitors (EGFR TKIs). Novel EGFR TKIs have been developed or repurposed for these mutants. A limited number of preclinical studies have detailed these EG...

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Detalles Bibliográficos
Autores principales:	Vasconcelos, Pedro E.N.S., Kobayashi, Ikei S., Kobayashi, Susumu S., Costa, Daniel B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Brief Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7959160/ https://www.ncbi.nlm.nih.gov/pubmed/33728415 http://dx.doi.org/10.1016/j.jtocrr.2020.100105

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