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Pathologic Response Rates after Neoadjuvant Therapy for Sarcoma: A Single Institution Study
SIMPLE SUMMARY: For high-grade soft tissue sarcomas (STS), combined modality treatment with surgery and radiation therapy is the standard of care. The addition of chemotherapy has been shown to decrease the risk of local recurrence and improve survival. Evaluating treatment response with surrogate m...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7959282/ https://www.ncbi.nlm.nih.gov/pubmed/33802383 http://dx.doi.org/10.3390/cancers13051074 |
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author | Seldon, Crystal Shrivastava, Gautam Fernandez, Melanie Jarboe, John Conway, Sheila Pretell, Juan Freedman, Laura Wolfson, Aaron Zhao, Wei Kwon, Deukwoo Rosenberg, Andrew Subhawong, Ty Trent, Jonathan Yechieli, Raphael |
author_facet | Seldon, Crystal Shrivastava, Gautam Fernandez, Melanie Jarboe, John Conway, Sheila Pretell, Juan Freedman, Laura Wolfson, Aaron Zhao, Wei Kwon, Deukwoo Rosenberg, Andrew Subhawong, Ty Trent, Jonathan Yechieli, Raphael |
author_sort | Seldon, Crystal |
collection | PubMed |
description | SIMPLE SUMMARY: For high-grade soft tissue sarcomas (STS), combined modality treatment with surgery and radiation therapy is the standard of care. The addition of chemotherapy has been shown to decrease the risk of local recurrence and improve survival. Evaluating treatment response with surrogate modalities such as MRI, CT and PET imaging have substantial limitations. Pathologic necrosis of the surgical specimen is a direct indicator of the effect of treatment on tumor cells. Studies in STS and other malignancies have shown that increasing rates of treatment-induced tumor necrosis correlate with improvement of oncological outcomes and survival. However, the relationship between pathologic response and outcomes of specific neoadjuvant treatments for STS remains indeterminate. We hypothesized that sequential neoadjuvant chemotherapy and radiation yields higher rates of pathologic complete response (pCR) than neoadjuvant radiation or chemotherapy alone. Our results indicate that neoadjuvant chemotherapy and radiation yields superior pCR compared to other neoadjuvant regimens. ABSTRACT: (1) Background: Pathologic necrosis of soft tissue sarcomas (STS) has been used to determine treatment response, but its relationship to neoadjuvant treatments remains indeterminate. In this retrospective, single institution study, we hypothesized that neoadjuvant chemoradiation (NA-CRT) yields higher rates of pathologic complete response (pCR) than neoadjuvant radiation (NA-XRT) or chemotherapy (NA-CT) alone. (2) Methods: Patients with extremity STS between 2011–2020 who received neoadjuvant treatment were included. pCR was defined as percent necrosis of the surgical specimen greater than or equal to 90%. (3) Results: 79 patients were analyzed. 51.9% of the population were male with a mean age of 58.4 years. 49.4% identified as Non-Hispanic White. Twenty-six (32.9%) patients achieved pCR while 53 (67.1%) did not. NA-CT (OR 15.82, 95% CI = 2.58–96.9, p = 0.003 in univariate (UVA) and OR 24.7, 95% CI = 2.88–211.2, p = 0.003 in multivariate (MVA), respectively) and NA-XRT (OR 5.73, 95% CI = 1.51–21.8, p = 0.010 in UVA and OR 7.95, 95% CI = 1.87–33.7, p = 0.005 in MVA, respectively) was significantly associated with non- pCR when compared to NA-CRT. The analysis also demonstrated that grade 3 tumors, when using grade 2 as reference, also had significantly higher odds of achieving pCR (OR 0.23, 95% CI = 0.06–0.80, p = 0.022 in UVA and OR 0.16, 95% CI = 0.04–0.70, p = 0.015 in MVA, respectively). (4) Conclusion: NA-CRT yields superior pCR compared to other neoadjuvant regimens. This extends to higher grade tumors. |
format | Online Article Text |
id | pubmed-7959282 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79592822021-03-16 Pathologic Response Rates after Neoadjuvant Therapy for Sarcoma: A Single Institution Study Seldon, Crystal Shrivastava, Gautam Fernandez, Melanie Jarboe, John Conway, Sheila Pretell, Juan Freedman, Laura Wolfson, Aaron Zhao, Wei Kwon, Deukwoo Rosenberg, Andrew Subhawong, Ty Trent, Jonathan Yechieli, Raphael Cancers (Basel) Article SIMPLE SUMMARY: For high-grade soft tissue sarcomas (STS), combined modality treatment with surgery and radiation therapy is the standard of care. The addition of chemotherapy has been shown to decrease the risk of local recurrence and improve survival. Evaluating treatment response with surrogate modalities such as MRI, CT and PET imaging have substantial limitations. Pathologic necrosis of the surgical specimen is a direct indicator of the effect of treatment on tumor cells. Studies in STS and other malignancies have shown that increasing rates of treatment-induced tumor necrosis correlate with improvement of oncological outcomes and survival. However, the relationship between pathologic response and outcomes of specific neoadjuvant treatments for STS remains indeterminate. We hypothesized that sequential neoadjuvant chemotherapy and radiation yields higher rates of pathologic complete response (pCR) than neoadjuvant radiation or chemotherapy alone. Our results indicate that neoadjuvant chemotherapy and radiation yields superior pCR compared to other neoadjuvant regimens. ABSTRACT: (1) Background: Pathologic necrosis of soft tissue sarcomas (STS) has been used to determine treatment response, but its relationship to neoadjuvant treatments remains indeterminate. In this retrospective, single institution study, we hypothesized that neoadjuvant chemoradiation (NA-CRT) yields higher rates of pathologic complete response (pCR) than neoadjuvant radiation (NA-XRT) or chemotherapy (NA-CT) alone. (2) Methods: Patients with extremity STS between 2011–2020 who received neoadjuvant treatment were included. pCR was defined as percent necrosis of the surgical specimen greater than or equal to 90%. (3) Results: 79 patients were analyzed. 51.9% of the population were male with a mean age of 58.4 years. 49.4% identified as Non-Hispanic White. Twenty-six (32.9%) patients achieved pCR while 53 (67.1%) did not. NA-CT (OR 15.82, 95% CI = 2.58–96.9, p = 0.003 in univariate (UVA) and OR 24.7, 95% CI = 2.88–211.2, p = 0.003 in multivariate (MVA), respectively) and NA-XRT (OR 5.73, 95% CI = 1.51–21.8, p = 0.010 in UVA and OR 7.95, 95% CI = 1.87–33.7, p = 0.005 in MVA, respectively) was significantly associated with non- pCR when compared to NA-CRT. The analysis also demonstrated that grade 3 tumors, when using grade 2 as reference, also had significantly higher odds of achieving pCR (OR 0.23, 95% CI = 0.06–0.80, p = 0.022 in UVA and OR 0.16, 95% CI = 0.04–0.70, p = 0.015 in MVA, respectively). (4) Conclusion: NA-CRT yields superior pCR compared to other neoadjuvant regimens. This extends to higher grade tumors. MDPI 2021-03-03 /pmc/articles/PMC7959282/ /pubmed/33802383 http://dx.doi.org/10.3390/cancers13051074 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Seldon, Crystal Shrivastava, Gautam Fernandez, Melanie Jarboe, John Conway, Sheila Pretell, Juan Freedman, Laura Wolfson, Aaron Zhao, Wei Kwon, Deukwoo Rosenberg, Andrew Subhawong, Ty Trent, Jonathan Yechieli, Raphael Pathologic Response Rates after Neoadjuvant Therapy for Sarcoma: A Single Institution Study |
title | Pathologic Response Rates after Neoadjuvant Therapy for Sarcoma: A Single Institution Study |
title_full | Pathologic Response Rates after Neoadjuvant Therapy for Sarcoma: A Single Institution Study |
title_fullStr | Pathologic Response Rates after Neoadjuvant Therapy for Sarcoma: A Single Institution Study |
title_full_unstemmed | Pathologic Response Rates after Neoadjuvant Therapy for Sarcoma: A Single Institution Study |
title_short | Pathologic Response Rates after Neoadjuvant Therapy for Sarcoma: A Single Institution Study |
title_sort | pathologic response rates after neoadjuvant therapy for sarcoma: a single institution study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7959282/ https://www.ncbi.nlm.nih.gov/pubmed/33802383 http://dx.doi.org/10.3390/cancers13051074 |
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