Knock-Down of HDAC2 in Human Induced Pluripotent Stem Cell Derived Neurons Improves Neuronal Mitochondrial Dynamics, Neuronal Maturation and Reduces Amyloid Beta Peptides

Histone deacetylase 2 (HDAC2) is a major HDAC protein in the adult brain and has been shown to regulate many neuronal genes. The aberrant expression of HDAC2 and subsequent dysregulation of neuronal gene expression is implicated in neurodegeneration and brain aging. Human induced pluripotent stem ce...

Descripción completa

Detalles Bibliográficos
Autores principales: Frankowski, Harald, Yeboah, Fred, Berry, Bonnie J., Kinoshita, Chizuru, Lee, Michelle, Evitts, Kira, Davis, Joshua, Kinoshita, Yoshito, Morrison, Richard S., Young, Jessica E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7959288/
https://www.ncbi.nlm.nih.gov/pubmed/33802405
http://dx.doi.org/10.3390/ijms22052526

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7959288/
https://www.ncbi.nlm.nih.gov/pubmed/33802405
http://dx.doi.org/10.3390/ijms22052526

Ejemplares similares