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RNF111-facilitated neddylation potentiates cGAS-mediated antiviral innate immune response

The cytosolic DNA sensor cyclic GMP-AMP (cGAMP) synthetase (cGAS) has emerged as a fundamental component fueling the anti-pathogen immunity. Because of its pivotal role in initiating innate immune response, the activity of cGAS must be tightly fine-tuned to maintain immune homeostasis in antiviral r...

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Detalles Bibliográficos
Autores principales:	Li, Chenhui, Zhang, Lele, Qian, Dong, Cheng, Mingxing, Hu, Haiyang, Hong, Ze, Cui, Ye, Yu, Huansha, Wang, Quanyi, Zhu, Juanjuan, Meng, Wei, Xu, Jin-fu, Sun, Yi, Zhang, Peng, Wang, Chen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7959372/ https://www.ncbi.nlm.nih.gov/pubmed/33720974 http://dx.doi.org/10.1371/journal.ppat.1009401

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