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Inhibition of innate immune response ameliorates Zika virus-induced neurogenesis deficit in human neural stem cells
Global Zika virus (ZIKV) outbreaks and their strong link to microcephaly have raised major public health concerns. ZIKV has been reported to affect the innate immune responses in neural stem/progenitor cells (NS/PCs). However, it is unclear how these immune factors affect neurogenesis. In this study...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7959377/ https://www.ncbi.nlm.nih.gov/pubmed/33657175 http://dx.doi.org/10.1371/journal.pntd.0009183 |
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author | Xu, Pei Gao, Junling Shan, Chao Dunn, Tiffany J. Xie, Xuping Xia, Hongjie Zou, Jing Thames, Beatriz H. Sajja, Amulya Yu, Yongjia Freiberg, Alexander N. Vasilakis, Nikos Shi, Pei-Yong Weaver, Scott C. Wu, Ping |
author_facet | Xu, Pei Gao, Junling Shan, Chao Dunn, Tiffany J. Xie, Xuping Xia, Hongjie Zou, Jing Thames, Beatriz H. Sajja, Amulya Yu, Yongjia Freiberg, Alexander N. Vasilakis, Nikos Shi, Pei-Yong Weaver, Scott C. Wu, Ping |
author_sort | Xu, Pei |
collection | PubMed |
description | Global Zika virus (ZIKV) outbreaks and their strong link to microcephaly have raised major public health concerns. ZIKV has been reported to affect the innate immune responses in neural stem/progenitor cells (NS/PCs). However, it is unclear how these immune factors affect neurogenesis. In this study, we used Asian-American lineage ZIKV strain PRVABC59 to infect primary human NS/PCs originally derived from fetal brains. We found that ZIKV overactivated key molecules in the innate immune pathways to impair neurogenesis in a cell stage-dependent manner. Inhibiting the overactivated innate immune responses ameliorated ZIKV-induced neurogenesis reduction. This study thus suggests that orchestrating the host innate immune responses in NS/PCs after ZIKV infection could be promising therapeutic approach to attenuate ZIKV-associated neuropathology. |
format | Online Article Text |
id | pubmed-7959377 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-79593772021-03-25 Inhibition of innate immune response ameliorates Zika virus-induced neurogenesis deficit in human neural stem cells Xu, Pei Gao, Junling Shan, Chao Dunn, Tiffany J. Xie, Xuping Xia, Hongjie Zou, Jing Thames, Beatriz H. Sajja, Amulya Yu, Yongjia Freiberg, Alexander N. Vasilakis, Nikos Shi, Pei-Yong Weaver, Scott C. Wu, Ping PLoS Negl Trop Dis Research Article Global Zika virus (ZIKV) outbreaks and their strong link to microcephaly have raised major public health concerns. ZIKV has been reported to affect the innate immune responses in neural stem/progenitor cells (NS/PCs). However, it is unclear how these immune factors affect neurogenesis. In this study, we used Asian-American lineage ZIKV strain PRVABC59 to infect primary human NS/PCs originally derived from fetal brains. We found that ZIKV overactivated key molecules in the innate immune pathways to impair neurogenesis in a cell stage-dependent manner. Inhibiting the overactivated innate immune responses ameliorated ZIKV-induced neurogenesis reduction. This study thus suggests that orchestrating the host innate immune responses in NS/PCs after ZIKV infection could be promising therapeutic approach to attenuate ZIKV-associated neuropathology. Public Library of Science 2021-03-03 /pmc/articles/PMC7959377/ /pubmed/33657175 http://dx.doi.org/10.1371/journal.pntd.0009183 Text en © 2021 Xu et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Xu, Pei Gao, Junling Shan, Chao Dunn, Tiffany J. Xie, Xuping Xia, Hongjie Zou, Jing Thames, Beatriz H. Sajja, Amulya Yu, Yongjia Freiberg, Alexander N. Vasilakis, Nikos Shi, Pei-Yong Weaver, Scott C. Wu, Ping Inhibition of innate immune response ameliorates Zika virus-induced neurogenesis deficit in human neural stem cells |
title | Inhibition of innate immune response ameliorates Zika virus-induced neurogenesis deficit in human neural stem cells |
title_full | Inhibition of innate immune response ameliorates Zika virus-induced neurogenesis deficit in human neural stem cells |
title_fullStr | Inhibition of innate immune response ameliorates Zika virus-induced neurogenesis deficit in human neural stem cells |
title_full_unstemmed | Inhibition of innate immune response ameliorates Zika virus-induced neurogenesis deficit in human neural stem cells |
title_short | Inhibition of innate immune response ameliorates Zika virus-induced neurogenesis deficit in human neural stem cells |
title_sort | inhibition of innate immune response ameliorates zika virus-induced neurogenesis deficit in human neural stem cells |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7959377/ https://www.ncbi.nlm.nih.gov/pubmed/33657175 http://dx.doi.org/10.1371/journal.pntd.0009183 |
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