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Twelfth-Position Deuteration of Nevirapine Reduces 12-Hydroxy-Nevirapine Formation and Nevirapine-Induced Hepatocyte Death

[Image: see text] Cytochrome P450-dependent metabolism of the anti-HIV drug nevirapine (NVP) to 12-hydroxy-NVP (12-OHNVP) has been implicated in NVP toxicities. We investigated the impact of twelfth-position trideuteration (12-D(3)NVP) on the hepatic metabolism of and response to NVP. Formation of 1...

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Detalles Bibliográficos
Autores principales:	Heck, Carley J. S., Seneviratne, Herana Kamal, Bumpus, Namandjé N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7959450/ https://www.ncbi.nlm.nih.gov/pubmed/32065749 http://dx.doi.org/10.1021/acs.jmedchem.9b01990

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